NFL Week 10 Predictions, Picks, Props and Best Bets for Every Game

It only took a month, but after a horrendous two-week stretch early in the season, I'm finally back to .500. I obviously have much higher expectations for myself than that, but I do feel like I have a bit better pulse of certain teams now. There's so many divisional matchups in Week 10 that I think it could have the potential to muck up the works, but we'll try to trudge on.

Week 9 Record ATS: 9-5
Week 9 Record on Totals: 9-5

2025 Season Record ATS: 60-60
2025 Season Record on Totals: 65-56

NFL Week 10 Picks For Each Game

NFL Week 10 Predictions

In this article, we also take a look at NFL Week 10 odds and our predictions for each NFL game. Home teams are listed last.

Raiders vs. Broncos

Division games are weird and I am worried about the absence of Patrick Surtain (pectoral) obviously doesn't help either. But come on. Las Vegas just feels perpetually inepet. And I'm not going to overreact because they played less poorly against a Jacksonville team that I've lost any bit of faith in.

Spread Pick: Broncos -9.5
Total Pick: Under 44.5

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Falcons vs. Colts

Indianapolis paid a heavy pricy to beef up its secondary with Tuesday's acquisition of Sauce Gardner, but I do admire the move. Even if you think the 2022 first-round pick is a depreciating asset, it's the type of trade that tells your organization, the players and the fans that a division crown and some mediocre effort in the postseason isn't enough anymore. As for this game, I'm a little worried we're going to get the good side of the Jekyll and Hyde Falcons, but in the same breath I'd be a bit surprised if Jonathan Taylor is kept in check once again. I do have some degree of confidence we're not going to see a ton of points in this one, if only because I think both teams will be happy to escape the overseas trip with a win as opposed to exerting their will offensively.

Spread Pick: Colts -6.5
Total Pick: Under 48.5

Saints vs. Panthers

This line seems suspicious to me. Carolina is not a very good team, but New Orleans seems like its easily one of the worst in the league. I'd have assumed the Panthers would be favored by closer to a touchdown, but division games of course can get weird. If you can convince me the Saints can score more than 17 points I'm all for assuming a cover will be in play, I just don't know reasonably how that happens with Tyler Shough under center.

Spread Pick: Panthers -5.5
Total Pick: Under 39.5

Giants vs. Bears

I don't feel good about the Bears covering at all, but there's just going to be so many points involved in this game that I have to imagine someone wins by a touchdown one way or another.

Spread Pick: Bears -4.5
Total Pick: Over 46.5

Jaguars vs. Texans

This line has swung dramatically with C.J. Stroud out with a concussion. I'm far from a Davis Mills supporter, but I don't think Jacksonville has done nearly enough to be a road favorite against a division opponent with the type of consistent defensive performance Houston possesses. 

Spread Pick: Texans +1.5
Total Pick: Under 37.5

Bills vs. Dolphins

I'd really like to assume the Bills will just take care of business. They obviously should. Something tells me, however, this could be a letdown week after an emotional win over the Chiefs. Buffalo has been liable to have those types of games in the past, and it feels like especially this year they're prone to that sort of error. I'd be surprised if they lost, but this just has the makings of a game that has no business being close entering the fourth quarter.

Spread Pick: Dolphins +9.5
Total Pick: Under 50.5

Ravens vs. Vikings

Both the spread and total are aggressive lines given the J.J. McCarthy offense isn't exactly potent and the Ravens have been far from world beaters this season, but I understand what Vegas is doing. The return of Lamar Jackson should effectively make Baltimore a top-of-the-line contender, and I have confidence the multi-time MVP will have enough mobility to maneuver around whatever defensive coordinator Brian Flores throws at him. 

Spread Pick: Ravens -4.5
Total Pick: Under 48.5

Browns vs. Jets

Please do everything you can to pretend this game doesn't exist.

Spread Pick: Browns -2.5
Total Pick: Over 37.5

Patriots vs. Buccaneers 

Thankfully we're blessed with a much better game that involves an AFC East team than the one above. I do not think the Patriots are a true 7-2 team. I have to imagine any of Baltimore, Kansas City and Buffalo will be lining up to face either Indianapolis or New England when the time comes in the postseason. But its undeniable how good Drake Maye has played this year, and we know Tampa's secondary is gettable. Potentially no Bucky Irving (foot/shoulder) is also a significant issue and this might be the one week Tampa Bay can't get by with spare parts offensively.

Spread Pick: Patriots +2.5
Total Pick: Over 48.5

Cardinals vs. Seahawks 

Vegas is begging you to bet on the Seahawks to cover, but I'm not falling for it. If Kyler Murray (ankle/poor play) was starting this would be a no brainer to me, but Jacoby Brissett just has this offense absolutely humming. Ironically I think Seattle has done the most to make me have a 180 opinion of them from when the year started, but even good teams can have a bad game every once awhile. Especially against a division opponent that has everything to lose.

Spread Pick: Cardinals +6.5
Total Pick: Over 45.5

Rams vs. 49ers

I have absolutely zero read on this game. Los Angeles should have annihilated the 49ers a couple of weeks ago on Thursday Night Football, and yet Kyle Shanahan performed his magic once again. This one is in San Francisco, and theoretically the 49ers could be getting healthier too. Typically every NFC West team splits against one another, but at the very least I have to think San Fran will be in position to cover

Spread Pick: 49ers +4.5
Total Pick: Over 49.5

Lions vs. Commanders

This probably won't be much of a contest. Detroit's loss to Minnesota wasn't all that surprising to me, but they rarely lay an egg twice. Washington's offensive woes will obviously draw headlines with no Terry McLaurin (quadriceps) and Jayden Daniels (elbow), but their defense quietly is playing horribly too.

Spread Pick: Lions -7.5
Total Pick: Under 49.5

Steelers vs. Chargers

While I wasn't surprised by the MIN/DET result last week, I was shocked how Pittsburgh managed to beat Indianapolis last week. Maybe I shouldn't be given the Steelers seem to inexplicably coax opponents into doing the thing they normally are incredibly good at avoiding, whether that be turnovers, special teams errors, inefficient third-down conversion, all of the above, etc. With Joe Alt (ankle) now done for the season, I think there's real concerns we're going to see the fall off of Los Angeles' offense in the near future. It could even come this week.

Spread Pick: Steelers +3
Total Pick: Over 45.5

Eagles vs. Packers

There's really absolutely zero reason the Packers should be favored in this one. I'm about as diehard of a Packers fan as they come, and I can't give you a logical reason as to how they'll win. That's basically the only reason I have any degree of faith -- simply because when GB's back is against the wall -- and ONLY when it's back against the wall, do they perform the way you'd expect.

Spread Pick: Packers -2.5
Total Pick: Over 45.5

NFL Week 10 Best Bets

Next, we take a look at our favorite Week 10 NFL best bets at the best NFL betting sites. As has been the case for most of the season, I went about .500 with my various calls. We'll aim to surpass that mark this week.

BetMGM Best Bets for NFL Week 10

BetMGM offers some of the best odds available for Week 10. If you're not signed up at BetMGM yet, new players at BetMGM can use the BetMGM bonus code ROTOBONUS for a risk-free bet worth up to $1,000. Here are our NFL best bets for Week 10 at BetMGM.

• Three-team DEN/LV parlay (+120) - Bo Nix 200+ passing yards, Broncos moneyline, over 34.5 total points

Caesars Sportsbook Best Bets for NFL Week 10

Caesars Sportsbook also has great betting odds for NFL Week 10. If you are not registered yet, use the Caesars Sportsbook promo code ROTOFULL for a first bet on Caesars.

• CHI/NYG over 47 points (-105)
• LAC/PIT over 44.5 points (-114)

DraftKings Best Bets for NFL Week 10

The DraftKings Sportsbook has special offers for new users just in time for Week 10 of the NFL season. Here are our best picks available at the DraftKings Sportsbook this week.

• Ravens -4.5 (-102)
• Cardinals +6.5 (-105)

FanDuel Best Bets for NFL Week 10

One of the most popular sportsbooks available is FanDuel Sportsbook. Let's take a look at our favorite betting picks with FanDuel odds.

• LAC/PIT three-item parlay (+628) - Chargers win first half, Steelers +1.5-point favorite second half, Steelers moneyline
• CAR/NO first half under 19.5 total points (+110)

BetRivers Best Bets for NFL Week 10

BetRivers is an up-and-coming and underrated sportsbook, and they are offering up to $500 in second-chance bets with the BetRivers bonus code. Bettors can use those for these picks on NFL Week 10.

• NO/CAR under 4.5 total touchdowns (-143)

Fanatics Sportsbook Best Bets for NFL Week 10

For bettors looking for a unique way to wager, try the Fanatics Sportsbook promo code for our Week 10 NFL picks.

• Steelers +2.5 (+100)

Look ahead at the NFL Week 11 odds as well, if you're interested in getting ahead of the line movement.