RotoWire.com, where we review the best sports betting apps, once again asked ChatGPT to project this week's NFL games.
We ran 10 AI simulations for each NFL Week 10 matchup, requesting results with game scores for each simulation and using NFL rosters and injury updates as of Nov. 5. We also asked the program to provide the margin of victory for each matchup. RotoWire found these simulated results from AI:
ChatGPT Predicts NFL Week 10 Results
Matchup | Result | Visitors Avg. MOV | Home Avg.MOV |
LV at DEN | 8-2 | 1.0 | 12.0 |
ATL vs. IND* | 6-4 | 3.0 (ATL) | 2.2 (IND) |
NO at CAR | 7-3 | 1.7 | 10.1 |
NYG at CHI | 8-2 | 3.0 | 5.0 |
JAX at HOU | 7-3 | 3.0 | 5.6 |
BUF at MIA | 8-2 | 5.8 | 2.0 |
BAL at MIN | 7-3 | 2.0 | 5.9 |
CLE at NYJ | 5-5 | 3.6 | 6.8 |
NE at TB | 6-4 | 4.8 | 6.0 |
ARI at SEA | 7-3 | 3.0 | 8.0 |
LAR at SF | 6-4 | 4.0 | 5.8 |
DET at WAS | 7-3 | 4.0 | 5.7 |
PIT at LAC | 6-4 | 3.5 | 4.2 |
PHI at GB | 5-5 | 3.6 | 4.8 |
Broncos
Falcons
Panthers
Bears
Texans
Bills
Vikings
Seahawks
49ers
Lions
Chargers*Neutral-site game in Berlin, Germany
Teams on a bye: Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs, Tennessee Titans
Check out Week 10 NFL odds with us and remember, the moneylines and spreads for this week's NFL games might not align with these AI projections.
Which Week 10 Games Are Too Close To Call?
Two games are right down the middle at 5-5 after 10 ChatGPT game projections this week.
The Cleveland Browns and New York Jets square off in a matchup that, technically, somebody has to win. Unless these teams tie out of sheer mutual incompetence, which we cannot rule out.
So let's put our NFL betting focus on the Super Bowl champion 
Philadelphia Eagles, and perhaps their biggest threat to repeat, in a gem of a Monday Night Football showdown.
The 
Green Bay Packers are projected to split in 10 simulated meetings with Philly.
Jordan Love and company are averaging 360.4 yards per game and 5.9 yards per play (the latter figure is fifth in the NFL). The metrics are not as kind to Philadelphia, which is in the middle of the pack in yards per play (5.3) and 24th in yards per game (304.4).
But the NFL standings don't care about metrics and the Eagles (6-2) hold the No. 1 seed in a tightly packed NFC playoff race. The North-leading Packers (5-2-1) are No. 4, having dropped from the top spot after last week's loss to Carolina.
BetMGM Sportsbook has Green Bay as a 2.5-point favorite as of Nov. 5.
Another strong matchup takes place at Raymond James Stadium, where the 
Tampa Bay Buccaneers will try to fend off a surprising contender.
The New England Patriots (7-2) enter this game as the No. 2 seed in the AFC, fending off the 6-2 Buffalo Bills for the lead in the East division. The Bucs, meanwhile, head a relatively weak NFC South at 6-2, despite missing key receivers Mike Evans and Chris Godwin plus running back Bucky Irving.
Bucs quarterback Baker Mayfield is fifth in current NFL MVP odds, at a number varying from +1500 to +2200 depending on the sportsbook operator. Not bad for a guy who is on his fourth NFL team.
AI projects the Bucs to win by a 6-4 margin over 10 simulated games, but the margins are close.
Week 10 NFL Projections Q&A
Q: How did ChatGPT simulate NFL Week 10 games?
A: RotoWire ran 10 simulations for every Week 10 matchup using ChatGPT, with rosters updated as of Nov. 5, 2025. Each game produced projected scores, a winner, and a calculated average margin of victory (MOV). This allowed us to compare not only who wins most often but also how decisively they win.
Q: Which teams dominated the ChatGPT simulations?
A: The biggest hitters were the Broncos (8-2, average +12.0 point margin of victory against the Raiders) and Panthers (7-3, average MOV +10.1 against the Saints). Others with simulated matchups tilting heavily in their favor were the (8-2, +5.8 visitor MOV at the Dolphins), Bears (8-2, +5.0 vs. the Giants), Seahawks (7-3, +8.0 vs. the Cardinals), Texans (7-3, +5.6 against the Jaguars), and Vikings (7-3, +5.9 vs. the Ravens). Other teams with solid average MOVs were the 49ers (6-4, +5.8 vs. the Rams) and Lions (7-3, +5.7 against the Commanders).
Q: What were the closest or most balanced matchups in the simulations?
A: True toss-ups were Browns at Jets and Eagles at Packers, both at 5-5 after 10 AI simulations. Relatively tight 6-4 splits included Falcons vs Colts (MOVs ~3.0 vs 2.2), Patriots at Buccaneers (4.8 vs 6.0), Rams at 49ers (4.0 vs 5.8), and Steelers at Chargers (3.5 vs 4.2).
