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Best Bets for Buffalo Bills vs. Houston Texans | Houston Texans +5.5 (-110)
Josh Allen and the Buffalo Bills will look to build off a win over Tampa Bay in Week 11 on the road against Houston. bet365 oddsmakers have the Texans valued as +5.5 point home underdogs with a 44.0 point total.
NFL fans who claim bet365 Bonus Code ROTOWIRE can get $150 in bonus bets, win or lose, after placing a $5 first bet on any sport. Target any of our Thursday Night Football best bets below to qualify for this excellent bet-and-get welcome offer.
For our first best bet, we're going to continue riding Davis Mills and the Texans' top-ranked scoring defense. Houston has won two straight games without QB1 C.J. Stroud, as he continues to be kept in the league's concussion protocol.
The Texans have covered +5.5 in four consecutive games, going 3-1 SU during this recent stretch. They grinded out an ugly 16-13 win via a walk-off field goal on the road against the Tennessee Titans in Week 11.
Buffalo's offense has been sporadic in 2025. The Bills have lost on the road against the Falcons and the Dolphins, forcing the offense to become one-dimensional with Allen as a pocket passer.
Houston's stingy defense is going to keep the offense ahead of schedule. Buffalo cannot stop the run, so expect the Texans to dial up a lot of rush attempts for their backfield tonight.
We're grabbing the points with Houston as a home underdog. Let's take the Texans +5.5 for our first best bet on Thursday Night Football.
Best Bets for Buffalo Bills vs. Houston Texans | Davis Mills U 209.5 Passing Yards (-110)
We've already outlined Houston's game plan against Buffalo. The Texans are going to feed their running backs carries against a weak Bills run defense, limiting Davis Mills as a passer.
Mills has logged over 270 passing yards in both starts against Jacksonville and Tennessee. That's going to change against Buffalo, who have held opposing quarterbacks under 210 passing yards in three of their last four games played.
As long as Houston takes an early lead and melts the clock with long, methodical drives leaning on Woody Marks and Nick Chubb, Mills won't be tasked with a lot of pass attempts. Even if the game script goes against our favor, the Bills are very good at defending the pass.
Let's fade Mills as a passer and bet under 209.5 passing yards in a tough matchup against Buffalo's secondary.
Best Bets for Buffalo Bills vs. Houston Texans | Woody Marks Anytime Touchdown Scorer (+125)
Woody Marks has overtaken Nick Chubb as Houston's RB1. The Texans' fourth-round rookie selection out of USC has logged between 14 and 18 carries during Mills' two starts, leading to a rushing touchdown against the Jaguars.
Marks is built to finish drives in the red zone. He's scored only twice this season, yet Buffalo's weak run defense presents a favorable matchup to target Marks' anytime touchdown scorer prop at +125 odds.
The Bills have allowed eight rushing touchdowns across their last three games played. Six of these were by opposing running backs, so let's place one more bet on Woody Marks' +!25 odds in the anytime touchdown scorer prop betting market.
Buffalo Bills vs. Houston Texans Picks
- Houston Texans +5.5 (-110)
- Davis Mills U 209.5 Passing Yards (-110)
- Woody Marks Anytime Touchdown Scorer (+125)
Best Events to Use the bet365 Bonus Code For November 20
- NFL: Buffalo Bills vs. Houston Texans. Bills -5.5 on the road with a 44.0 point total. Kickoff at 8:15 p.m. ET on Prime Video.
- College Football: Louisiana Ragin' Cajuns vs. Arkansas State Red Wolves. Arkansas State -2.5 at home with a 54.5 point total.
- College Basketball: Wake Forest Demon Deacons vs. Texas Tech Red Raiders. Baha Mar Championship game from Nassau, Bahamas. 8:30 p.m. ET tip-off on CBSSN.
- NHL: New Jersey Devils vs. Florida Panthers. The 13-win Devils travel to Sunrise, Florida, to take on the defending Stanley Cup champions. Puck drop at 7 p.m. ET on ESPN+.
- NBA. Atlanta Hawks vs. San Antonio Spurs. Spurs star forward Victor Wembanyama's calf injury leaves him sidelined during tonight's matchup. 8 p.m. ET tip-off on NBA TV.
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