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The Buccaneers need to get the ball to Mike Evans, and it's not obvious what the Giants defense can do to stop it.
At 6-4 the Texans might need to fully unleash Nico Collins in his first game back, because they can't afford to take a fifth loss at the hands of Dallas.
The Chargers might not throw much by design, but if the Bengals offense scores quickly then Ladd McConkey might be busy as the Chargers try to keep pace.
The Ravens might want to shadow George Pickens with Marlon Humphrey, because the other Ravens corners can't cover Pickens.
Kyren Williams is likely in line for a big game against a weak Miami run defense.
Amon-Ra St. Brown could be productive against a Houston defense that doesn't move around its corners, allowing Detroit to avoid Derek Stingley.
Deebo Samuel could go nuts as the desperate 49ers take aim at a weak Tampa Bay corner rotation.
Baker Mayfield has thrown seven interceptions in his last three games, and without his top two wideouts he could throw a few more interceptions at Arrowhead on Monday.
Michael Pittman has struggled through a back injury, but if the injury has improved then Pittman could get back on track with Joe Flacco at quarterback.
Justin Jefferson will almost certainly have a big game Sunday, and the Colts pass defense is weak enough for Jordan Addison to get rolling in the same game.
The arrival of Russell Wilson lifts up the Pittsburgh passing game, but it also makes life easier for Najee Harris, who could keep rolling Monday.
The 49ers need Jordan Mason to carry the offense Sunday, and he's likely prepared to do so.
With Tua Tagovailoa back in the lineup Jaylen Waddle should get rolling against Arizona, and the same is true of Tyreek Hill if he plays through his foot injury.
The Cardinals must get the ball to Marvin Harrison more, and the Chargers' beat-up corner rotation might provide a get-right game Monday.
Secondary Ravens pass catchers like Rashod Bateman might get open against Tampa Bay's weak cornerback rotation.
The Steelers hope Russell Wilson can improve the Pittsburgh passing game, but the fading veteran steps into a challenging situation Sunday night.
Drake London's breakout should continue against a Seattle secondary that might be without its two starting boundary corners.
If the Jets really mean to commit to the ground game then they'll have to prove it by feeding Breece Hall against the Bills on Monday.
Tyrone Tracy showed up big for the Giants in Week 5, and they'll need to call on him again with Devin Singletary (groin) unavailable against Cincinnati on Sunday night.
The showdown between Detroit and Dallas could set up a punch-for-punch heavyweight contest where CeeDee Lamb and Amon-Ra St. Brown both go off.
Derek Carr has a career average of just 6.3 yards per pass against the Chiefs, and now he needs to play at Arrowhead with an interior offensive line decimated by injury.
Dak Prescott is without Brandin Cooks against a dangerous Pittsburgh defense, but he should need to throw the ball often given Dallas' rushing struggles.
Michael Pittman got back on track in Week 4 and should keep it rolling in Week 5, as neither the Jags nor Colts have viable coverage personnel.
Despite three weeks of struggles to open the 2024 season, Jared Goff is in a good bounce-back spot Monday night.
The Miami run defense is much more inviting than any Tony Pollard has seen in his first three games with Tennessee.
Derrick Henry finally got rolling in Week 3, but he faces a much tougher defense Sunday night than the Dallas one from Week 3.
George Pickens should get going against an Indianapolis defense with questionable boundary personnel
The Commanders are heavy road underdogs, but Brian Robinson should still be busy against a beat-up and questionable Bengals run defense.
Josh Allen could do big damage Monday, but it's also not clear if the Bills will need to ask much of him against a sinking Jaguars squad.
With both offenses struggling through two weeks it's likely crucial to pursue Bijan Robinson's assured usage in single-game lineups between Atlanta and Kansas City on Sunday night.
If Patrick Surtain shadows Mike Evans on the boundary then it could create a target funnel to Chris Godwin in the slot.
With A.J. Brown (hamstring) unavailable, DeVonta Smith becomes extremely difficult to fade against Atlanta on Monday.
C.J. Stroud is generally stronger at home than on the road, but the Bears defense is strong enough to raise the difficulty level Sunday night.
Amon-Ra St. Brown will likely torch a thin Buccaneers secondary playing without its star enforcer in Antoine Winfield.
There's both hope and apprehension for the Jets offense as Aaron Rodgers returns from last year's Achilles' tendon tear on the road and against a dangerous 49ers defense.
Jahmyr Gibbs is reportedly over his hamstring injury, setting up for a monster box score against the Aaron Donald-less Rams on Sunday night.
There's a lot to keep track of as the Eagles face the Packers, but the headlining stories might be star free agent RB pickups Saquon Barkley and Josh Jacobs.
Mike Evans has to slow down eventually, but probably not against Washington's undersized boundary corners.
In the final installment of our top-150 Roundtable Rankings, Rashee Rice continues to rise as suspension fears subside.
Isaac Guerendo missed almost all of training camp due to injuries, but his 4.33 speed will play well in the 49ers offense if he can get healthy.
After two disappointing seasons Jalen Tolbert appears to have turned a corner for Dallas and offers breakout upside as the Cowboys' WR3.
Third overall draft pick Drake Maye will begin the season on the bench behind Jacoby Brissett.
The Browns will reportedly leave Nick Chubb on the PUP List going into the regular season, ruling him out for at least Cleveland's first four games and leaving Jerome Ford as the starting running back.
James Cook had his likely career year in 2023, making him a poor purchase now that his price is higher than ever.
The latest installment of our Roundtable Rankings saw some upheaval in the top 5 as Christian McCaffrey is no longer the unanimous No. 1 overall.
RotoWire football writers gathered to debate their favorite sleepers and busts for the 2024 season. Who's undervalued, who's overvalued?
Breaking down four wideout competitions, including how the 49ers receivers behind Brandon Aiyuk fit into the SF offense.
DeMario Douglas might rarely leave the slot for the Patriots, but his per-snap target rate could be high enough to make him the fantasy WR1 in New England.
Aaron Jones isn't built to withstand volume, so the Vikings might need to call upon Ty Chandler for spot starts in 2024.
In the fourth installment of our top-150 Roundtable Rankings, DeAndre Hopkins took a steep drop on the news of his injured knee.