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MORE: Best sports betting promos
Best Bets for Thursday Night Football | Buffalo Bills -12 (-110)
The Buffalo Bills host the Miami Dolphins on Thursday Night Football to kick off the Week 3 slate. Oddsmakers are bullish on Josh Allen and the Bills, laying -12 on the point spread, with a point total set at 49.5.
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It's been a nightmare start to the 2025 season for the Miami Dolphins. At 0-2, another loss on the road at Buffalo would drop the Dolphins to 0-2 in the AFC East division, while prompting further discussions about firing head coach Mike McDaniel.
There's no question which team is more desperate ahead of Thursday night. Miami getting +12 on the point spread is tempting; however, they are facing arguably the best team in the league on the road.
Our initial best bet for Week 3 Thursday Night Football is to lay the big number and back Buffalo -12 at home against a divisional opponent that is completely devoid of confidence.
Best Bets for Thursday Night Football | De'Von Achane Anytime Touchdown Scorer (+110)
As bad as it's been for Miami, the offense still has talented playmakers. Particularly running back De'Von Achane, who has found the end zone during both of the Dolphins' losses in 2025.
Achane is the RB1, but essentially functions as a wide receiver, logging 14 targets out of the backfield. He's scored both touchdowns as a receiver, while tallying 11 or fewer carries in each game played.
Buffalo's run defense looked much improved against the Jets in Week 2. However, Achane's versatility in the passing game makes him a difficult player to cover.
The Dolphins will be in scoring position at least a couple of times, whether early or potentially in garbage time at the end of a blowout loss. Achane is the betting favorite for Miami in the Anytime Touchdown Scorer player prop market.
Let's continue to ride the hot hand and bet on Achane's Anytime Touchdown Scorer odds at +110.
Best Bets for Thursday Night Football | Tua Tagovailoa U 240.5 Passing Yards (-120)
The final best bet to place for Thursday Night Football in Week 3 is on Tua Tagovailoa to finish with fewer than 241 passing yards. Miami's QB1 sailed over this line against New England in Week 2, logging 315 passing yards and two touchdowns. However, Buffalo's secondary is a big step up in competition in comparison to the Patriots' secondary, which gave up over 300 passing yards to Geno Smith in Week 1.
Factor in Buffalo's familiarity with Miami due to playing twice a year in the same division. Tagovailoa has not gone over 240.5 passing yards in three straight matchups against the Bills, although one of those was cut short due to injury.
Based on the disgruntled state of the Dolphins, plus facing a Super Bowl contender on the road in prime-time, let's fade Tagovailoa. Bet under 240.5 passing yards at -120.
Thursday Night Football Picks
- Buffalo Bills -12 (-110)
- De'Von Achane Anytime Touchdown Scorer (+110)
- Tua Tagovailoa U 240.5 Passing Yards (-120)
Best Events to Use the BetMGM Bonus Code For on September 17th
- MLB: San Francisco Giants vs. Arizona Diamondbacks. Two National League West rivals find themselves in a high-stakes matchup. Each team is within two games of occupying an NL Wild Card spot.
- MLB: Cleveland Guardians vs. Detroit Tigers. An American League Central tilt with Cleveland, which is red-hot, going 9-1 SU in its last 10 games played. The Guardians are currently three games out of the final AL Wild Card seed.
- WNBA: Phoenix Mercury vs. New York Liberty. The Liberty holds a 1-0 lead in this best-of-3 playoff series against the Mercury. New York is -2.5 on the point spread with a 159.5 point total at home in Barclays Center.
