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The Pirates announced Wednesday that Simon has been diagnosed with a torn labrum in his left shoulder and will undergo surgery in October once the bone heals, MLB.com reports.
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Burrows is slated to start Sunday's game against the Nationals in Washington.
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Chandler is slated to start Saturday's game against the Nationals in Washington.
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Keller did not factor into the decision Friday, allowing two runs on four hits and one walk over 5.1 innings in a 6-5 loss against Washington. He struck out four.
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The Pirates optioned Holderman to Triple-A Indianapolis on Friday.
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The Pirates reinstated Lawrence (elbow) from the 60-day injured list Friday.
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Pham is absent from the lineup for Friday's contest against the Nationals.
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Suwinski (groin) went 1-for-3 with a solo home run Thursday in a rehab appearance with Triple-A Indianapolis.
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Oviedo did not factor into the decision Thursday against the Orioles, allowing two runs on five hits and three walks across 5.2 innings. He struck out five.
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Davis is not in the lineup for Thursday's contest in Baltimore.
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Devanney is out of the lineup for Thursday's game in Baltimore.
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Bae went 0-for-2 with two walks and two stolen bases in Wednesday's 2-1 extra-inning loss to the Orioles.
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Skenes came away with a no-decision in Wednesday's 2-1 extra-inning loss to the Orioles, allowing only two hits over five scoreless innings. He struck out eight without walking a batter.
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Gonzales is out of the lineup for Wednesday's game against the Orioles.
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McCutchen is out of the lineup for Wednesday's game against the Orioles.
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Santana threw a scoreless inning while not allowing a baserunner and striking out one Tuesday against the Orioles.
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Ashcraft allowed one earned run on two hits and two walks while striking out four across three innings Wednesday against the Orioles.
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Burrows allowed one run on two hits and a walk while striking out six over four innings Tuesday versus the Orioles. He did not factor into the decision.
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Pham went 1-for-4 with a solo home run and a walk in Tuesday's loss to the Orioles.
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Chandler (2-1) allowed nine runs on nine hits and three walks over 2.2 innings Sunday, striking out three and taking a loss against the Brewers.
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Burrows is listed as the Pirates' probable starting pitcher for Tuesday's game in Baltimore.
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Devanney is out of the lineup for Sunday's game against the Brewers.
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Davis is out of the lineup for Sunday's game against the Brewers.
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Pham is out of the lineup for Sunday's game against the Brewers.
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The Pirates optioned Kreidler to Triple-A Indianapolis on Sunday.
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