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Pham went 1-for-3 with a two-run home run during Monday's 9-3 loss to Kansas City.
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Heaney (4-8) took the loss Monday against the Royals, allowing four runs on six hits and one walk over three innings. He struck out two.
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The Pirates activated Holderman (thumb) from the 15-day injured list Monday and optioned him to Triple-A Indianapolis, Colin Beazley of the Pittsburgh Post-Gazette reports.
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Horwitz is out of the lineup for Monday's game against the Royals.
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Bart is out of the lineup for Monday's game against the Royals.
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Cruz is not in the lineup for Monday's game in Kansas City.
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Skenes pitched five scoreless innings, allowing five hits and no walks in a no-decision Sunday at Seattle. He struck out 10.
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Ramirez re-signed Sunday with the Pirates on minor-league contract.
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Hayes is out of the lineup for Sunday's game against the Mariners.
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Bart is out of the lineup for Sunday's game against the Mariners.
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Burrows didn't factor in the decision Saturday against the Mariners after allowing three hits and four walks over five shutout innings. He struck out six.
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Lawrence (elbow) progressed to throwing from 120 feet Wednesday, MLB.com reports.
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Mayza (shoulder) progressed to throwing from 120 feet Wednesday, MLB.com reports.
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Borucki (back) resumed throwing bullpen sessions Wednesday, MLB.com reports.
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Falter (6-4) took the loss Friday against the Mariners, giving up four runs (three earned) on three hits and no walks in 5.2 innings. He struck out four.
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Pham is not in Friday's lineup against the Mariners.
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Kiner-Falefa went 1-for-3 with a two-run single in Wednesday's 5-0 win over St. Louis.
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Pham went 2-for-4 with two RBI and a run scored in Wednesday's 5-0 win over the Cardinals.
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Keller (3-10) earned the win against the Cardinals on Wednesday, allowing five hits and one walk while striking out seven batters in seven scoreless innings.
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Kiner-Falefa went 1-for-3 with two RBI in Wednesday's 5-0 win over the Cardinals.
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Frazier is out of the lineup for Wednesday's game against the Cardinals.
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Pham will start in left field and bat seventh in Wednesday's game against the Cardinals.
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Bart is not in the lineup for Wednesday's game versus the Cardinals.
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Bednar gave up a hit and a walk in a scoreless ninth inning Tuesday to record his 12th save of the season in a 1-0 win over the Cardinals.
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Skenes didn't factor into the decision in Tuesday's 1-0 win over the Cardinals, allowing five hits and a walk over five innings. He struck out five.
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