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The Astros are expected to recall Whitcomb from Triple-A Sugar Land on Tuesday, Ari Alexander of KPRC 2 Houston reports.
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The Astros placed Pena on the 10-day injured list Monday due to a small rib fracture on his left side.
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Altuve went 1-for-4 with a two-run home run during Sunday's 2-0 win over the Cubs.
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Hader picked up the save Sunday against the Cubs, striking out one during a perfect ninth inning.
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Valdez (9-4) picked up the win Sunday against the Cubs, allowing five hits and two walks with six strikeouts over six scoreless innings.
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VanWey (undisclosed) struck out a batter and allowed no hits and no walks over a scoreless inning of relief for Triple-A Sugar Land on Saturday after being reinstated from the 7-day injured list.
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McCormick (oblique) will report to the Astros' spring facility in Florida to face live pitching this week, Brian McTaggart of MLB.com reports.
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Caratini is out of the lineup for Sunday's game against the Cubs.
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Astros general manager Dana Brown said Sunday that Alvarez (hand) has a chance to return from the 10-day injured list for next weekend's series against the Dodgers, though Brown added that is "not the most likely scenario," Chandler Rome of The Athletic reports.
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Pena (ribs) is out of the lineup for Sunday's game against the Cubs, Brian McTaggart of MLB.com reports.
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Arrighetti (thumb) completed another bullpen session Friday, his second since landing on the injured list April 8, MLB.com reports.
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Garcia (elbow) has begun throwing live batting practice sessions at Houston's spring training complex in Florida, MLB.com reports.
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Alvarez (hand) took 25 swings in the batting cage Saturday and is scheduled to do so again Sunday, MLB.com reports.
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Paredes went 2-for-3 with a solo home run and a hit-by-pitch in Saturday's loss to the Cubs.
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McCullers (1-3) took the loss against the Cubs on Saturday, allowing eight runs on seven hits and four walks while striking out one batter over 3.1 innings.
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Pena (ribs) is not in the Astros' starting lineup against the Cubs on Saturday, Matt Kawahara of the Houston Chronicle reports.
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The Astros optioned Hernandez to Triple-A Sugar Land following Friday's game against the Cubs.
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The Astros reinstated McCullers (foot) from the 15-day injured list ahead of his scheduled start against the Cubs on Saturday.
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Smith went 2-for-2 with a three-run home run, two walks and two total runs scored in Friday's 7-4 win over the Cubs.
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Diaz went 3-for-4 with a three-run home run in Friday's 7-4 win over the Cubs.
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Hader retired the only batter he faced to earn the save in Friday's 7-4 win over the Cubs.
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Walter (1-1) allowed a run on five hits and struck out five without walking a batter over six innings to earn the win over the Cubs on Friday.
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McCullers (foot) will come off the 15-day injured list Saturday and start against the Cubs, Brian McTaggart of MLB.com reports.
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Astros manager Joe Espada told reporters after Friday's 7-4 win over the Cubs that imaging on Pena's ribs came back negative and did not show any fracture, Matt Kawahara of the Houston Chronicle reports.
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Pena was removed from Friday's game against the Cubs due to left rib soreness, Matt Kawahara of the Houston Chronicle reports.
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