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Texans vs Bills Odds, Lines, Spreads & Totals 2025

Bills
24.5 Pts
Texans
19.0 Pts
Thursday November 20, 2025 at 8:15 PM ET
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BUF
Bills Injury Report
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HOU
Texans Injury Report
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BUF
Bills Lineup
Inactives
    None reported yet.
HOU
Texans Lineup
Inactives
    None reported yet.
BUF
Bills News
#5 WR
Curtis Samuel: Sitting out practice Tuesday
Nov 18th
Bills head coach Sean McDermott said that Samuel (elbow/neck) won't practice Tuesday, Joe Buscaglia of The Athletic reports.
#6 WR
Mecole Hardman: Not practicing Tuesday
Nov 18th
Bills head coach Sean McDermott said that Hardman (calf) won't participate in Tuesday's walk-through practice, Joe Buscaglia of The Athletic reports.
#1 TE
Dalton Kincaid: Not practicing Tuesday
Nov 18th
Bills head coach Sean McDermott said that Kincaid (hamstring) won't participate in Tuesday's walk-through practice, Joe Buscaglia of The Athletic reports.
#1 RCB
Christian Benford: Still working through groin injury
Nov 17th
Benford (groin) was limited during Monday's walkthrough practice, Alec White of the Bills' official site reports.
#1 MLB
Terrel Bernard: Limited in Monday's walkthrough
Nov 17th
Bernard (ankle) was a limited participant during Monday's walkthrough practice, Alec White of the Bills' official site reports.
#2 WLB
Shaq Thompson: Full practice at walkthrough
Nov 17th
Thompson (hamstring) was listed as a full participant on Monday's estimated practice report.
#3 TE
Jackson Hawes: Fails to catch pass in Week 11 win
Nov 17th
Hawes wasn't targeted in the Bills' win over the Bucs on Sunday.
#3 RB
Ray Davis: Impact limited to return game again
Nov 17th
Davis played one of 56 offensive snaps during Buffalo's 44-32 win over the Buccaneers in Week 11. He also fielded four kick returns, tallying 158 yards on special teams.
#3 WR
Joshua Palmer: Will be limited Monday
Nov 17th
Bills head coach Sean McDermott said Monday that Palmer (undisclosed) will be limited in practice, Matt Parrino of The Syracuse Post-Standard reports.
#1 FS
Cole Bishop: Nabs another pick in win
Nov 17th
Bishop recorded six total tackles (three solo) and one interception in Sunday's 44-32 win over the Buccaneers.
#1 SS
Jordan Poyer: Notches 15 stops vs. Tampa Bay
Nov 17th
Poyer recorded 15 total tackles (seven solo) and one pass defensed in Sunday's 44-32 win over the Buccaneers.
#2 TE
Dawson Knox: Catches one pass in Week 11 win
Nov 17th
Knox caught one of three targets for 23 yards in Sunday's 44-32 win over Tampa Bay.
#1 WR
Khalil Shakir: Shut down in big win
Nov 16th
Shakir brought in one of three targets for minus-3 yards in the Bills' 44-32 win over the Buccaneers on Sunday.
#1 K
Matt Prater: Uneventful day in blowout win
Nov 16th
Prater made his only field-goal attempt and went 5-for-5 on PATs in Sunday's 44-32 victory over Tampa Bay.
#1 RB
James Cook: Claws way to over 100 total yards
Nov 16th
Cook rushed 16 times for 48 yards and secured all three targets for 66 yards in the Bills' 44-32 win over the Buccaneers on Sunday.
#2 RB
Ty Johnson: Finds paydirt in Week 11
Nov 16th
Johnson recorded one carry for nine yards and caught both of his targets for 61 yards and a touchdown in Sunday's 44-32 win over Tampa Bay.
#4 WR
Tyrell Shavers: Makes most of added opportunities
Nov 16th
Shavers caught four of five targets for 90 yards and a touchdown in Sunday's 44-32 win over the Buccaneers.
#1 QB
Josh Allen: All-time performance in win
Nov 16th
Allen completed 19 of 30 passes for 317 yards with three touchdowns and two interceptions while adding six carries for 40 yards and three more scores in the Bills' 44-32 win over the Buccaneers on Sunday.
#2 SCB
Cam Lewis: Active Sunday, as is Taron Johnson
Nov 16th
Lewis (calf) is active for Sunday's Week 11 battle against the Buccaneers.
#7 WR
Elijah Moore: Inactive Sunday
Nov 16th
Moore is inactive for Sunday's game against the Buccaneers.
#1 SCB
Taron Johnson: Cleared for Week 11
Nov 16th
Johnson (groin) is active for Sunday's tilt against Tampa Bay.
#2 WR
Keon Coleman: Inactive Sunday
Nov 16th
Coleman is inactive for Sunday's game against the Buccaneers.
#3 DT2
T.J. Sanders: Activated from IR
Nov 15th
The Bills activated Sanders (knee) from injured reserve Saturday, though he is still listed as questionable for Sunday's game against Tampa Bay.
#3 LDT
Phidarian Mathis: Won't play vs. Buccaneers
Nov 14th
Mathis (shoulder) is out for Sunday's game versus Tampa Bay, Maddy Glab of the Bills' official site reports.
#2 LDE
A.J. Epenesa: Good to go
Nov 14th
Epenesa (concussion) has no injury designation ahead of Sunday's matchup against the Buccaneers.
#1 RDE
Joey Bosa: Logs four stops Sunday
Nov 11th
Bosa logged four solo tackles during Buffalo's loss to Miami on Sunday.
#3 LDE
Landon Jackson: Placed on IR
Nov 11th
The Bills placed Jackson (knee) on injured reserve Tuesday.
#1 DT2
DaQuan Jones: Cleared to play Miami
Nov 9th
Jones (calf) is active for Sunday's game against the Dolphins.
HOU
Texans News
#1 SCB
Jalen Pitre: Ruled out for TNF
Nov 18th
Coach DeMeco Ryans said Pitre (concussion) will not play in Thursday night's game against the Bills, DJ Bien-Aime of ESPN.com reports.
#2 QB
Davis Mills: Ticketed for third straight start
Nov 18th
Head coach DeMeco Ryans said that Mills will serve as the Texans' starting quarterback for Thursday's game against the Bills, Aaron Wilson of KPRC 2 Houston reports.
#1 QB
C.J. Stroud: Ruled out for Thursday night
Nov 18th
Texans head coach DeMeco Ryans ruled Stroud (concussion) out for Thursday's game against the Bills, DJ Bien-Aime of ESPN.com reports.
#1 SS
Calen Bullock: Makes six stops again Sunday
Nov 17th
Bullock finished Sunday's 16-13 win over Tennessee with six tackles (three solo).
#1 RCB
Kamari Lassiter: Posts two stops in Week 11 win
Nov 17th
Lassiter recorded two tackles (one solo) and a defensed pass Sunday in a 16-13 victory versus Tennessee.
#2 SCB
Myles Bryant: Paces Texans in tackles Sunday
Nov 17th
Bryant logged eight tackles (four solo) in Sunday's 16-13 win against Tennessee.
#1 RG
Ed Ingram: Returns to full practice
Nov 17th
Ingram was estimated to be a full practice participant Monday.
#1 RT
Tytus Howard: Limited to begin Week 12 prep
Nov 17th
Howard (knee/ankle) was estimated to be a limited practice participant Monday.
#1 LDE
Will Anderson: Nursing ankle injury
Nov 17th
Houston listed Anderson (ankle) as a limited practice participant on Monday's estimated report.
#1 MLB
Azeez Al-Shaair: Estimated as LP to open week
Nov 17th
The Texans listed Al-Shaair (knee/illness) as a limited participant on Monday's estimated practice report.
#1 K
Ka'imi Fairbairn: Full listing Monday
Nov 17th
Fairbairn (right quadriceps) was listed as full on Monday's practice estimate.
#1 TE
Dalton Schultz: Still dealing with shoulder issue
Nov 17th
Schultz (shoulder) was listed as limited on Monday's estimated injury report.
#1 WR
Nico Collins: Limited by ankle issue
Nov 17th
Collins was limited at Monday's walkthrough due to an ankle injury.
#1 RDE
Danielle Hunter: Another dominant performance Sunday
Nov 17th
Hunter recorded four total tackles (one solo), including 1.5 sacks, in Sunday's 16-13 win over the Titans.
#4 WR
Jaylin Noel: Up-and-down season continues
Nov 17th
Noel hauled in his lone target for 12 yards while adding 89 total return yards on five punts and two kickoffs in Sunday's 16-13 win over the Titans in Week 11.
#3 WR
Christian Kirk: Another quiet outing
Nov 17th
Kirk secured one of four targets for six yards in Sunday's 16-13 win over Tennessee in Week 11.
#2 TE
Cade Stover: Untargeted in win
Nov 17th
Stover played 14 snaps and was not targeted in Sunday's 16-13 win over the Titans in Week 11.
#2 RB
Nick Chubb: Smallest role of season
Nov 16th
Chubb rushed three times for 17 yards and failed to bring in either of his two targets in the Texans' 16-13 win over the Titans on Sunday.
#1 RB
Woody Marks: Subdued showing in good matchup
Nov 16th
Marks rushed for 18 times for 44 yards and brought in his only target for seven yards in the Texans' 16-13 win over the Titans on Sunday.
#2 K
Matthew Wright: Plays hero in Week 11
Nov 16th
Wright went 3-for-3 on field-goal attempts and made his only PAT in Sunday's 16-13 win over the Titans.
#5 WR
Xavier Hutchinson: Posts 42 yards in Week 11 win
Nov 16th
Hutchinson caught three of five targets for 42 yards in the Texans' 16-13 win over the Titans on Sunday.
#2 WR
Jayden Higgins: Another seven targets Sunday
Nov 16th
Higgins secured four catches (on seven targets) for 55 yards during Sunday's 16-13 win in Tennessee.
#3 LOLB
Jamal Hill: Won't return due to hamstring issue
Nov 16th
Hill (hamstring) has been ruled out for the rest of Sunday's game against the Titans.
#1 FB
Jakob Johnson: Ready for Week 11
Nov 16th
Johnson (hamstring) is active for Sunday's game against the Titans.
#6 WR
Braxton Berrios: Won't play against Tennessee
Nov 16th
Berrios (coach's decision) is inactive for Sunday's game against the Titans.
#4 RB
Dameon Pierce: Healthy scratch Week 11
Nov 16th
Pierce (coach's decision) is inactive for Sunday's game against the Titans.
#3 TE
Harrison Bryant: Placed on injured reserve
Nov 15th
The Texans placed Bryant (neck/shoulder) on injured reserve Saturday.
#2 ROLB
Christian Harris: Returns to full practice
Nov 13th
Harris (shin) practiced in full Thursday.
#2 SS
M.J. Stewart: Officially lands on IR
Nov 12th
Stewart (quadriceps) was placed on injured reserve Wednesday.
#1 LCB
Derek Stingley: Records third pickoff
Nov 11th
Stingley registered two assisted tackles and two defensed passes, including an interception, in a 36-29 win against the Jaguars on Sunday.
#3 RDE
Dylan Horton: Returns to practice Wednesday
Nov 5th
Horton (knee) was a full participant in Houston's practice Wednesday.
#2 RCB
Jaylin Smith: Heads to IR
Nov 5th
Smith (undisclosed) was placed on the injured reserve list Wednesday.
#3 LDE
Darrell Taylor: Shifts to IR
Nov 5th
Taylor (ankle) was placed on the injured reserve list Wednesday.