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Saints vs Cardinals Odds, Lines, Spreads & Totals 2025

Cardinals
24.3 Pts
Saints
18.3 Pts
Sunday September 7, 2025 at 1:00 PM ET
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Cardinals Injury Report
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Cardinals Lineup
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Cardinals News
#1 QB
Kyler Murray: Starters to sit Saturday
Aug 21st
Cardinals head coach Jonathan Gannon said Thursday that he plans to sit Arizona's starters and other key players during Saturday's preseason finale against the Raiders, as was the case during the team's second exhibition game against Denver, Darren Urban of the Cardinals' official site reports.
#2 WR
Michael Wilson: Doesn't play Saturday
Aug 18th
Wilson didn't suit up for Saturday's 27-7 preseason loss in Denver.
#2 RB
Trey Benson: DNP in preseason Week 2
Aug 18th
Benson didn't play in Saturday's 27-7 preseason loss at Denver.
#1 WR
Marvin Harrison: Better rapport with Murray
Aug 18th
Harrison and Kyler Murray are operating with a greater rapport ahead of the 2025 season, Zach Gershman of the Cardinals' official site reports.
#2 LG
Hayden Conner: Status for Week 1 in question
Aug 18th
Cardinals head coach Jonathan Gannon said Monday that Conner (knee) will "miss some time," Darren Urban of the Cardinals' official site reports.
#3 RB
Emari Demercado: Fills dual role in preseason loss
Aug 16th
Demercado rushed six times for 15 yards, failed to bring in his only target and returned two kickoffs for 60 yards in the Cardinals' 27-7 preseason loss to the Broncos on Saturday night.
#5 RB
Michael Carter: Heavy workload in preseason loss
Aug 16th
Carter rushed eight times for 10 yards and brought in all five targets for 19 yards in the Cardinals' 27-7 preseason loss to the Broncos on Saturday night.
#2 QB
Jacoby Brissett: Sharp in preseason loss
Aug 16th
Brissett completed six of eight passes for 57 yards with one touchdown and no interceptions in the Cardinals' 27-7 preseason loss to the Broncos on Saturday night. He also rushed once for two yards.
#1 DT2
Dalvin Tomlinson: Likely facing short absence
Aug 14th
Tomlinson (knee) won't practice Thursday, but coach Jonathan Gannon doesn't expect him to be sidelined for an extended period, Theo Mackie of AZCentral.com reports. "He's doing well but I didn't think it was the right thing to do to put him out there today," Gannon said.
#11 WR
Trishton Jackson: Placed on IR
Aug 12th
The Cardinals placed Jackson (thumb) on injured reserve Tuesday.
#2 SCB
Jaylon Jones: Two tackles in preseason debut
Aug 10th
Jones (shoulder) recorded two solo tackles in Saturday's 20-17 preseason win over the Chiefs.
#2 FS
Joey Blount: Four tackles versus KC
Aug 10th
Blount (illness) recorded four total tackles (two solo) in Saturday's 20-17 preseason win over the Chiefs.
#1 P
Blake Gillikin: Over foot injury
Aug 10th
Gillikin (foot) punted three times in Saturday's preseason opener against the Chiefs.
#2 RT
Christian Jones: Injures knee
Aug 10th
Cardinals head coach Jonathan Gannon said Saturday that Jones suffered a knee injury during the team's preseason opener, Bo Brack of GoPHNX.com reports.
#1 RB
James Conner: Three carries to open preseason
Aug 9th
Conner rushed three times for 11 yards in the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
#1 TE
Trey McBride: Big gain on one reception
Aug 9th
McBride brought in his only target for 21 yards during the Cardinals' 20-17 preseason win over the Chiefs on Saturday night.
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Saints News
#1 RT
Taliese Fuaga: Dealing with minor knee injury
Aug 21st
Fuaga (knee) didn't practice Thursday, Katherine Terrell of ESPN.com reports.
#2 QB
Tyler Shough: To be second QB up Saturday
Aug 21st
Shough will serve as the No.2 quarterback behind Spencer Rattler during Saturday's preseason finale against the Broncos, Matthew Paras of The New Orleans Times-Picayune reports.
#1 QB
Spencer Rattler: Starting preseason finale
Aug 21st
Rattler will start Saturday's preseason finale against the Broncos, Matthew Paras of The New Orleans Times-Picayune reports.
#4 WR
Devaughn Vele: Traded to New Orleans
Aug 20th
The Broncos agreed to terms Wednesday on a deal that sends Vele to the Saints in exchange for a 2026 fourth-round pick and a 2027 seventh-round pick.
#1 LS
Zach Wood: Working through hamstring injury
Aug 19th
Wood (hamstring) didn't participate in New Orleans' practice Tuesday, Katherine Terrell of ESPN reports.
#3 RDE
John Ridgeway: Dealing with pectoral injury
Aug 19th
Ridgeway is currently working through a pectoral injury, Matthew Paras of The New Orleans Times-Picayune reports.
#6 WR
Mason Tipton: Picks up 100 yards Sunday
Aug 17th
Tipton caught six of eight targets for 100 yards during Sunday's 17-17 preseason tie against Jacksonville.
#2 RB
Kendre Miller: Corralled versus Jacksonville
Aug 17th
Miller logged six carries for 21 yards during Sunday's 17-17 preseason tie versus Jacksonville.
#2 C
Luke Fortner: Traded to New Orleans
Aug 17th
The Jaguars traded Fortner to the Saints in exchange for defensive lineman Khalen Saunders on Sunday, Tom Pelissero of NFL Network reports.
#2 WR
Rashid Shaheed: Three catches in preseason tie
Aug 17th
Shaheed caught all three of his targets for 15 yards in Sunday's 17-17 preseason tie against the Jaguars.
#1 WR
Chris Olave: Catches two passes from rookie QB
Aug 17th
Olave (ankle) caught two of four targets for 12 yards in Sunday's 17-17 preseason tie against the Jaguars.
#1 RCB
Alontae Taylor: Not playing Sunday
Aug 17th
Taylor (groin) will not play in Sunday's preseason game against the Jaguars, Erin Summers of the Saints' official site reports.
#1 RB
Alvin Kamara: Won't play vs. Jacksonville
Aug 17th
Kamara is no longer in uniform and is not in line to play in Sunday's preseason game against the Jaguars, Erin Summers of the Saints' official site reports.
#3 RB
Devin Neal: Not in line to play Sunday
Aug 17th
Based on his absence from pregame warmups, Neal (hamstring) is not in line to play against the Jaguars in Sunday's preseason game, Matthew Paras of The New Orleans Times-Picayune reports.
#9 TE
Mason Pline: Reverts to IR with New Orleans
Aug 13th
Pline (upper body) reverted to injured reserve with the Saints on Wednesday, Aaron Wilson of KPRC 2 Houston reports.
#11 WR
Bub Means: Lands on injured reserve
Aug 13th
The Saints placed Means (lower leg) on the injured reserve list Wednesday, Ross Jackson of WWL Louisiana reports.
#4 C
Mike Panasiuk: Inks deal with New Orleans
Aug 12th
The Saints signed Panasiuk on Tuesday, Nick Underhill of NewOrleans.Football reports.
#3 NT
Jayden Peevy: Signs with Saints
Aug 12th
The Saints signed Peevy on Tuesday, Nick Underhill of NewOrleans.Football reports.
#5 C
Will Clapp: Done for 2025
Aug 12th
Clapp (foot) was placed on the Saints' injured reserve list Tuesday, Ross Jackson of WWL Louisiana reports.
#1 LG
Trevor Penning: Avoids major injury
Aug 12th
Penning is expected to miss just a few weeks with the foot injury he sustained during Sunday's preseason game against the Chargers, Ian Rapoport of NFL Network reports.
#8 TE
Seth Green: Rejoining Saints
Aug 12th
The Saints signed Green on Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#10 WR
Roderick Daniels: Signs with Saints
Aug 12th
The Saints signed Daniels on Tuesday, Aaron Wilson of KPRC 2 Houston reports.
#2 RCB
Rico Payton: Active for preseason opener
Aug 11th
Payton (illness) was active for the Saints' 27-13 preseason loss to the Chargers on Sunday.
#3 LILB
D'Marco Jackson: Checks into preseason opener
Aug 11th
Jackson (ankle) recorded one tackle (one solo) and a pass defensed during Sunday's 27-13 preseason loss against the Chargers.
#2 RILB
Jaylan Ford: Collects eight tackles Sunday
Aug 11th
Ford (fibula) recorded eight tackles (five solo) during Sunday's 27-13 preseason loss against the Chargers.
#1 TE
Juwan Johnson: Suits up for preseason loss
Aug 11th
Johnson (groin) played with the first-team offense during New Orleans' 27-13 preseason loss to the Chargers on Sunday.
#3 QB
Jake Haener: Third QB in game Sunday
Aug 10th
Haener completed five of his eight pass attempts for 41 yards and an interception during Sunday's 27-13 preseason loss to the Chargers.
#5 RB
Clyde Edwards-Helaire: Sees action in second half Sunday
Aug 10th
Edwards-Helaire logged four carries for six yards and caught his lone target for nine yards during Sunday's 27-13 preseason loss to the Chargers.
#7 WR
Kevin Austin: Sees five targets Sunday
Aug 10th
Austin caught four of five targets for 42 yards during Sunday's 27-13 preseason loss to the Chargers.
#4 RB
Cam Akers: Third RB to see touches Sunday
Aug 10th
Akers had four carries for nine yards and was not targeted as a receiver in Sunday's 27-13 preseason loss to the Chargers.