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Steelers vs Bills Odds, Lines, Spreads & Totals 2025

Bills
25.5 Pts
Steelers
22.0 Pts
Sunday November 30, 2025 at 4:25 PM ET
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BUF
Bills Injury Report
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PIT
Steelers Injury Report
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BUF
Bills Lineup
Inactives
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PIT
Steelers Lineup
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BUF
Bills News
#3 WR
Brandin Cooks: Finds new home in Buffalo
Nov 25th
Cooks signed a one-year contract with the Bills on Tuesday.
#4 RT
Tylan Grable: Practice window opened
Nov 24th
The Bills designated Grable (concussion) to return from injured reserve Monday, Alaina Getzenberg of ESPN.com reports.
#3 DT2
T.J. Sanders: Plays 16 snaps against Houston
Nov 23rd
Sanders recorded one tackle (zero solo) in Buffalo's loss to Houston on Thursday night.
#2 WLB
Shaq Thompson: Four tackles in TNF loss
Nov 23rd
Thompson recorded four tackles (zero solo) in Buffalo's loss to Houston on Thursday night.
#1 WLB
Matt Milano: Logs four tackles in loss
Nov 23rd
Milano recorded four tackles (two solo) in Thursday night's loss to the Texans.
#1 LDE
Greg Rousseau: Logs six tackles in TNF loss
Nov 23rd
Rousseau recorded six tackles (two solo) in Buffalo's loss to Houston on Thursday night.
#1 RCB
Christian Benford: Trio of tackles in TNF loss
Nov 23rd
Benford recorded three tackles (one solo) in Thursday night's loss to Houston.
#1 SCB
Taron Johnson: Five tackles in TNF defeat
Nov 23rd
Johnson recorded five tackles (three solo) and one pass breakup in Buffalo's loss to Houston on Thursday night.
#1 SS
Jordan Poyer: Six tackles in loss to Houston
Nov 23rd
Poyer recorded six tackles (two solo) in Thursday night's loss to the Texans.
#1 FS
Cole Bishop: Tallies six stops vs. Houston
Nov 21st
Bishop logged six tackles (three solo) during the Bills' 23-19 loss to the Texans on Thursday.
#1 RT
Spencer Brown: Nursing shoulder injury
Nov 21st
Bills head coach Sean McDermott said Friday that Brown sustained a shoulder injury in Thursday's 23-19 loss to the Texans and is a candidate to be placed on injured reserve, Joe Buscaglia of The Athletic reports.
#1 MLB
Terrel Bernard: Candidate for injured reserve
Nov 21st
Head coach Sean McDermott said Friday that Bernard (elbow) is a candidate to be placed on injured reserve, Joe Buscaglia of The Athletic reports.
#2 RCB
Maxwell Hairston: Placed in concussion protocol
Nov 21st
Hairston was placed in the concussion protocol Friday, Maddy Glab of the Bills' official site reports.
#7 WR
Curtis Samuel: Progressing in recovery
Nov 21st
Samuel (elbow/neck) is improving in his recovery, head coach Sean McDermott said Friday, Maddy Glab of the Bills' official site reports.
#1 TE
Dalton Kincaid: Making progress in recovery
Nov 21st
Kincaid (hamstring) is improving in his recovery, head coach Sean McDermott said Friday, Maddy Glab of the Bills' official site reports.
#1 QB
Josh Allen: Says he's fine after physical contest
Nov 21st
Allen had his left shoulder examined by athletic trainers during Thursday's 23-19 loss to the Texans but stayed in the game and told reporters "we're good" regarding the injury after the game, Alaina Getzenberg of ESPN.com reports.
#8 WR
Elijah Moore: One catch Thursday
Nov 21st
Moore caught one of three targets for minus-3 yards in Thursday's 23-19 loss to the Texans.
#4 WR
Gabe Davis: One catch in Week 12 loss
Nov 21st
Davis caught one of two targets for 22 yards in Thursday's 23-19 loss to the Texans.
#5 WR
Tyrell Shavers: No targets Thursday
Nov 21st
Shavers wasn't targeted in Thursday's 23-19 loss to the Texans.
#3 RB
Ray Davis: No touches but gets kick return TD
Nov 21st
Davis didn't record a carry or target in Thursday's 23-19 loss to the Texans but returned three kickoffs for 145 yards and a touchdown.
#2 WR
Joshua Palmer: Two catches in Thursday's loss
Nov 21st
Palmer caught two of four targets for 21 yards in Thursday's 23-19 loss to the Texans.
#2 RB
Ty Johnson: Solid as receiver in loss
Nov 20th
Johnson rushed twice for seven yards and brought in all three targets for 45 yards in the Bills' 23-19 loss to the Texans on Thursday night. He also returned one kickoff for 22 yards.
#1 WR
Khalil Shakir: Eclipses century mark in loss
Nov 20th
Shakir secured eight of 10 targets for 110 yards in the Bills' 23-19 loss to the Texans on Thursday night. He also lost a fumble and returned four punts for 15 yards.
#1 K
Matt Prater: Makes both FGAs in loss
Nov 20th
Prater went 2-for-2 on field-goal tries and made one of two PATs in Thursday night's 23-19 loss to the Texans.
#1 RB
James Cook: Nets 129 total yards, TD in loss
Nov 20th
Cook rushed 17 times for 116 yards and a touchdown while bringing in all three targets for 13 yards in the Bills' 23-19 loss to the Texans on Thursday night.
#3 LDT
Phidarian Mathis: Not yet ready to return
Nov 20th
Mathis (shoulder) is inactive for Thursday's Week 12 matchup against Houston.
#6 WR
Keon Coleman: Inactive versus Houston
Nov 20th
Coleman is inactive for Thursday night's game against the Texans.
#9 WR
Mecole Hardman: Lands on IR
Nov 20th
Hardman (calf) was placed on IR by the Bills on Thursday.
#3 TE
Jackson Hawes: Fails to catch pass in Week 11 win
Nov 17th
Hawes wasn't targeted in the Bills' 44-32 win over the Buccaneers on Sunday.
#2 TE
Dawson Knox: Catches one pass in Week 11 win
Nov 17th
Knox caught one of three targets for 23 yards in Sunday's 44-32 win over Tampa Bay.
#2 SCB
Cam Lewis: Active Sunday, as is Taron Johnson
Nov 16th
Lewis (calf) is active for Sunday's Week 11 battle against the Buccaneers.
#2 LDE
A.J. Epenesa: Good to go
Nov 14th
Epenesa (concussion) has no injury designation ahead of Sunday's matchup against the Buccaneers.
#1 RDE
Joey Bosa: Logs four stops Sunday
Nov 11th
Bosa logged four solo tackles during Buffalo's loss to Miami on Sunday.
PIT
Steelers News
#4 NT
Daniel Ekuale: Hit with five-game suspension
Nov 25th
The NFL suspended Ekuale five games Tuesday for violating the league's performance-enhancing drugs policy, Gerry Dulac of the Pittsburgh Post-Gazette reports.
#1 RCB
Joey Porter: Will be limited by hip
Nov 25th
Coach Mike Tomlin said Tuesday that Porter (hip) will be limited in practice this week, Alan Saunders of SteelersNow.com reports.
#1 WR
DK Metcalf: Likely to be limited by ankle issue
Nov 25th
Steelers head coach Mike Tomlin said Tuesday that Metcalf (ankle) will be a limited participant in practice early in Week 13 prep, Brooke Pryor of ESPN.com reports.
#1 QB
Aaron Rodgers: Limited to start Week 13 prep
Nov 25th
Head coach Mike Tomlin said Tuesday that Rodgers (wrist) will be a limited practice participant in the early portion of the week, but the Steelers have "great optimism" that the quarterback will be available Sunday versus the Bills, Gerry Dulac of the Pittsburgh Post-Gazette reports. "I'm comfortable with his general trajectory," Tomlin added.
#1 LT
Broderick Jones: Won't face Buffalo
Nov 25th
Coach Mike Tomlin said Monday that Jones (neck) has been ruled out for Sunday's game against the Bills, Gerry Dulac of the Pittsburgh Post-Gazette reports.
#1 RDE
Derrick Harmon: Ruled out for Week 13
Nov 25th
Steelers head coach Mike Tomlin said that Harmon has been ruled out for Sunday's game against the Bills, due to a knee injury, Gerry Dulac of the Pittsburgh Post-Gazette reports.
#1 FS
Jalen Ramsey: Nine takedowns in loss
Nov 24th
Ramsey registered nine total tackles (three solo) in Sunday's 31-28 loss to Chicago.
#1 LOLB
T.J. Watt: Strip sack in loss
Nov 24th
Watt recorded five total tackles (two solo), including 1.0 sacks, while also forcing a fumble in Sunday's 31-28 loss to the Bears.
#3 TE
Pat Freiermuth: Reaches end zone against Bears
Nov 24th
Freiermuth secured all three of his targets for 19 yards and a touchdown during Sunday's 31-28 loss to Chicago.
#2 TE
Jonnu Smith: Five touches against Chicago
Nov 24th
Smith secured all three of his targets for 21 yards while rushing twice for seven yards during Sunday's 31-28 loss to the Bears.
#1 TE
Darnell Washington: Racks up 22 yards in loss
Nov 24th
Washington secured both of his targets for 22 yards during Sunday's 31-28 loss to Chicago.
#3 WR
Roman Wilson: No catches in Week 12
Nov 24th
Wilson failed to secure either of his two targets during Sunday's 31-28 loss to the Bears.
#3 RB
Kaleb Johnson: Doesn't see field against Chicago
Nov 24th
Johnson didn't take the field during Sunday's 31-28 loss to Chicago.
#2 WR
Calvin Austin: Makes four catches
Nov 23rd
Austin recorded four receptions on five targets for 36 yards in Sunday's 31-28 loss to the Bears.
#1 K
Chris Boswell: No FGAs in loss
Nov 23rd
Boswell did not attempt a field goal and made all four of his PATs in Sunday's 31-28 loss to the Bears.
#1 RB
Jaylen Warren: Matches season high in carries
Nov 23rd
Warren rushed the ball 18 times for 68 yards and a touchdown in Sunday's 31-28 loss to the Bears.
#2 RB
Kenneth Gainwell: Tallies 122 yards from scrimmage
Nov 23rd
Gainwell rushed the ball 10 times for 92 yards in Sunday's 31-28 loss to the Bears. He added six receptions on six targets for 30 yards.
#2 QB
Mason Rudolph: Comes up short in spot start
Nov 23rd
Rudolph completed 24 of 31 passes for 171 yards, one touchdown and one interception in Sunday's 31-28 loss to the Bears. He added three rushes for seven yards while also losing a fumble.
#1 ROLB
Alex Highsmith: Not playing Week 12 as expected
Nov 23rd
Highsmith (pectoral) is inactive for Sunday's game against the Bears, Teresa Varley of the Steelers' official site reports.
#3 QB
Will Howard: Backup QB for Week 12
Nov 23rd
Howard is active for Sunday's game against the Bears, where he'll serve as the backup quarterback behind Mason Rudolph, Teresa Varley of the Steelers' official site reports.
#1 LCB
Darius Slay: Set to play Week 12
Nov 22nd
Slay (concussion) is expected to play Sunday against the Bears after having his injury designation removed Saturday, Brooke Pryor of ESPN.com reports.
#1 LDE
Cameron Heyward: Cleared of injury tag
Nov 22nd
Heyward (ankle) had his injury designation removed by Pittsburgh on Saturday, Brooke Pryor of ESPN.com reports.
#6 WR
Ke'Shawn Williams: Good to go for Week 12
Nov 21st
Williams (concussion) doesn't carry an injury designation into Sunday's game against the Bears, Mike DeFabo of The Athletic reports.
#1 SCB
Brandin Echols: Absent from injury report
Nov 19th
Echols (ankle) was a full participant in Wednesday's practice, Teresa Varley of the Steelers' official site reports.
#2 RCB
Cory Trice: Done for 2025
Nov 19th
Trice (hamstring/knee) will be sidelined for the rest of the season after he was not activated from injured reserve prior to Wednesday's deadline, Chris Adamski of TribLive.com reports.
#1 RILB
Cole Holcomb: Practices in full
Nov 19th
Holcomb (illness) was a full participant in practice Wednesday, Alan Saunders of SteelersNow.com reports.
#1 NT
Keeanu Benton: Three stops in Week 11 victory
Nov 18th
Benton posted three tackles (one solo) during the Steelers' 34-12 win over the Bengals on Sunday.
#2 RILB
Payton Wilson: Six stops vs. Cincinnati
Nov 18th
Wilson logged six tackles (four solo) during the Steelers' 34-12 win over the Bengals on Sunday.
#1 LILB
Patrick Queen: Secures 10 stops Sunday
Nov 17th
Queen finished with 10 tackles (five solo) in a 34-12 victory versus Cincinnati in Week 11 on Sunday.
#2 LCB
James Pierre: Returns fumble for TD in Week 11
Nov 17th
Pierre posted six tackles (three solo), two defensed passes and a fumble recovery, which he returned for a touchdown, in Sunday's 34-12 victory over the Bengals.
#1 SS
Kyle Dugger: Returns pick for TD
Nov 17th
Dugger recorded three tackles (all solo) and an interception, which he returned for a touchdown, in Sunday's 34-12 win over Cincinnati.
#1 LG
Isaac Seumalo: Cleared to play against Cincinnati
Nov 16th
Seumalo (pectoral) is active for Sunday's game against the Bengals.
#5 WR
Scotty Miller: Past finger injury
Nov 12th
Miller (finger) was a full participant in Wednesday's practice, Brooke Pryor of ESPN.com reports.
#2 FS
Jabrill Peppers: On track to play Week 11
Nov 12th
Peppers (quadriceps) was a full participant in Wednesday's practice, Brooke Pryor of ESPN.com reports.