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Bills vs Eagles Odds, Lines, Spreads & Totals 2025

Eagles
21.0 Pts
Bills
22.5 Pts
Sunday December 28, 2025 at 4:25 PM ET
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PHI
Eagles Injury Report
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BUF
Bills Injury Report
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PHI
Eagles Lineup
Inactives
    None reported yet.
BUF
Bills Lineup
Inactives
    None reported yet.
PHI
Eagles News
#1 RT
Lane Johnson: Absent from Tuesday's practice
Dec 23rd
Johnson (foot) was absent from Tuesday's practice, Jeff McLane of The Philadelphia Inquirer reports.
#1 RILB
Nakobe Dean: Could play through hamstring
Dec 23rd
Dean (hamstring) appears to have a chance to play this week, Brooks Kubena of The Athletic reports.
#1 LILB
Zack Baun: Leads Philly in tackles
Dec 21st
Baun recorded nine tackles (three solo) in Saturday's 29-18 win over the Commanders.
#1 SCB
Cooper DeJean: Picks off pass in win
Dec 21st
DeJean finished with five solo tackles and four pass breakups, including an interception, in Saturday's 29-18 win over the Commanders.
#3 WR
Jahan Dotson: Logs three catches vs. Washington
Dec 21st
Dotson caught three passes on as many targets for 13 yards during the Eagles' 29-18 win over the Commanders on Saturday.
#2 RB
Tank Bigsby: Gets into end zone Saturday
Dec 21st
Bigsby logged four rushes for 37 yards and a touchdown Saturday in a 29-18 Week 16 win over Washington.
#1 RDE
Jalen Carter: Likely to return in Week 17
Dec 21st
The Eagles are expected to have Carter (shoulders) available for their Week 17 game next Sunday in Buffalo, Adam Schefter of ESPN reports.
#2 WR
DeVonta Smith: Catches early TD in win
Dec 20th
Smith recorded six receptions on eight targets for 42 yards and a touchdown in Saturday's 29-18 win over the Commanders.
#1 TE
Dallas Goedert: Tallies another touchdown
Dec 20th
Goedert recorded three receptions on three targets for 32 yards and a touchdown in Saturday's 29-18 win over the Commanders.
#1 QB
Jalen Hurts: Solid showing in win
Dec 20th
Hurts completed 22 of 30 passes for 185 yards, two touchdowns and zero interceptions in Saturday's 29-18 win over the Eagles. He added seven rushes for 40 yards.
#1 RB
Saquon Barkley: Third 100-yard rushing performance
Dec 20th
Barkley rushed the ball 21 times for 132 yards and a touchdown in Saturday's 29-18 win over the Commanders. He did not record a catch on two targets.
#1 K
Jake Elliott: Poor performance in win
Dec 20th
Elliott converted all three extra points he attempted, but he missed both attempted field goals in Saturday's 29-18 win over the Commanders.
#1 WR
A.J. Brown: Nine catches against Commanders
Dec 20th
Brown recorded nine catches on 12 targets for 95 yards in Saturday's 29-18 win over the Commanders.
#4 TE
Cameron Latu: Inactive for Week 16
Dec 20th
Latu (neck) is inactive for Saturday's game against the Commanders.
#3 QB
Sam Howell: Emergency QB for Week 16
Dec 20th
Howell (coach's decision) is inactive but will serve as the Eagles' emergency third quarterback for Saturday's game against the Commanders.
#2 LT
Fred Johnson: Ready to face Week 16
Dec 18th
Johnson (ankle) does not carry an injury designation for Saturday's road matchup against the Commanders.
#2 RT
Fred Johnson: Ready to face Week 16
Dec 18th
Johnson (ankle) does not carry an injury designation for Saturday's road matchup against the Commanders.
#1 LG
Landon Dickerson: Ready to rock
Dec 18th
Dickerson (calf) does not carry an injury designation for Saturday's game against the Commanders.
#2 QB
Tanner McKee: Plays late in Week 15 blowout
Dec 17th
McKee rushed once for nine yards and completed all three of his pass attempts for 33 yards in Sunday's 31-0 win over the Raiders.
#5 WR
Britain Covey: Logs first offensive snaps of 2025
Dec 17th
Covey went without a target while playing four of the Eagles' 69 snaps on offense in Sunday's 31-0 win over the Raiders. He also returned three punts for 22 yards.
#2 TE
Grant Calcaterra: Notches sixth reception of 2025
Dec 17th
Calcaterra hauled in his lone target for a four-yard reception while playing 37 of 69 offensive snaps in Sunday's 31-0 win over the Raiders.
#4 WR
Darius Cooper: Ties season high with two catches
Dec 15th
Cooper caught both of his targets for 29 yards in Sunday's 31-0 win over the Raiders.
#3 RB
Will Shipley: No offensive touches in blowout win
Dec 15th
Shipley did not receive a carry or a target in Sunday's 31-0 win over the Raiders.
#1 LS
Charley Hughlett: Activated from IR
Dec 12th
The Eagles activated Hughlett (abdomen) from injured reserve Friday, and he carries no injury designation into Sunday's game against the Raiders.
#3 RT
Cameron Williams: Designated to return from IR
Dec 11th
The Eagles opened the practice window for Williams (shoulder) to return from injured reserve Thursday.
#3 LT
Myles Hinton: Staying on IR
Dec 11th
Hinton (back) had his 21-day practice window expire Wednesday without being activated from IR, per the NFL's official transactions log.
BUF
Bills News
#1 TE
Dalton Kincaid: DNP in Wednesday walk-through
Dec 24th
Kincaid (knee) was listed as a non-participant in Wednesday's walk-through practice.
#1 SS
Jordan Poyer: Doesn't practice Wednesday
Dec 24th
Poyer (hamstring) was a non-participant in Wednesday's walkthrough practice.
#1 QB
Josh Allen: Limited Wednesday, plans to play
Dec 24th
Allen (foot) was listed as limited in Wednesday's walk-through.
#1 SLB
Shaq Thompson: Limited in Wednesday's walkthrough
Dec 24th
Thompson (neck) was a limited participant in Wednesday's walkthrough practice.
#1 K
Matt Prater: Deemed DNP in Wednesday walkthrough
Dec 24th
Prater (quadriceps) was labeled as a non-participant in Wednesday's practice walkthrough.
#2 DT2
Jordan Phillips: DNP to open Week 17 prep
Dec 24th
Phillisp (ankle) did not participate in Wednesday's walkthrough practice.
#1 DT2
DaQuan Jones: Misses Wednesday's practice
Dec 24th
Jones (calf) didn't participate in Wednesday's walkthrough practice.
#1 RDE
Joey Bosa: Logs DNP on Wednesday
Dec 24th
Bosa (hamstring) didn't participate in Wednesday's walkthrough practice.
#2 TE
Dawson Knox: Dealing with knee issue
Dec 24th
Knox (knee) was deemed a non-participant in Wednesday's practice walkthrough.
#1 WLB
Matt Milano: Posts nine tackles in Week 16 win
Dec 23rd
Milano finished Sunday's 23-20 victory over the Browns with nine tackles (four solo).
#1 LDE
Greg Rousseau: Stands out with 2.5 sacks Sunday
Dec 23rd
Rousseau recorded three tackles, including 2.5 sacks, in Sunday's 23-20 Week 16 victory against Cleveland.
#1 FB
Reggie Gilliam: No touches in Week 16
Dec 22nd
Gilliam went without a carry or target while playing 11 of the Bills' 50 offensive snaps in Sunday's 23-20 win over the Browns.
#3 TE
Jackson Hawes: Catches two passes vs. Cleveland
Dec 22nd
Hawes caught both of his targets for 26 yards in Sunday's 23-20 win over the Browns.
#3 WR
Tyrell Shavers: Logs 21 yards in win
Dec 22nd
Shavers caught one of two targets for 21 yards during Sunday's 23-20 win over the Browns.
#2 WR
Joshua Palmer: Targeted once vs. Cleveland
Dec 22nd
Palmer caught his lone target for two yards in Sunday's 23-20 win over the Browns.
#4 WR
Brandin Cooks: No catches again Sunday
Dec 22nd
Cooks didn't catch his lone target during Sunday's 23-20 win over the Browns.
#3 RB
Ray Davis: More involved in Week 16
Dec 22nd
Davis rushed three times for 14 yards and caught both of his targets for 20 yards during Sunday's 23-20 win over the Browns. He also returned four kickoffs for 92 yards.
#1 RB
James Cook: Dominates in win over Browns
Dec 22nd
Cook carried the ball 16 times for 117 yards and two touchdowns during Buffalo's 23-20 win over Cleveland on Sunday. He also secured one of two targets for 17 yards.
#2 RB
Ty Johnson: Scores rush TD in win
Dec 21st
Johnson rushed three times for 16 yards and a touchdown in the Bills' 23-20 win over the Browns on Sunday.
#1 WR
Khalil Shakir: Team-high yardage in win
Dec 21st
Shakir secured four of five targets for 34 yards in the Bills' 23-20 win over the Browns on Sunday. He also returned one punt for three yards.
#7 WR
Gabe Davis: Inactive versus Cleveland
Dec 21st
Davis is inactive for Sunday's game against the Browns.
#6 WR
Keon Coleman: Inactive Sunday
Dec 21st
Coleman is inactive for Sunday's game against the Browns.
#2 SCB
Cam Lewis: Good to go Week 16
Dec 21st
Lewis (hamstring) is active for Sunday's game against the Browns.
#5 WR
Mecole Hardman: Cleared to play Week 16
Dec 21st
Hardman (calf) is active for Sunday's game against the Browns.
#4 RT
Chase Lundt: Heads to IR
Dec 19th
Lundt (knee) was placed on injured reserve Friday.
#1 SCB
Taron Johnson: Ready for Sunday
Dec 19th
Johnson (quadriceps) has no injury designation ahead of Sunday's matchup against the Browns.
#1 RCB
Christian Benford: Returning in Week 16
Dec 19th
Benford (toe) has no injury designation ahead of Sunday's matchup against the Browns.
#1 MLB
Terrel Bernard: Upgrades to full practice
Dec 18th
Bernard (elbow) was a full participant in Thursday's practice.
#2 RCB
Maxwell Hairston: Getting start Sunday
Dec 14th
Hairston will be one of Buffalo's starting cornerbacks in Week 15 versus New England as a result of Christian Benford missing the game due to a toe injury, Cameron Wolfe of NFL Network reports.
#1 RT
Spencer Brown: Set to start Sunday
Dec 12th
Brown (shoulder) doesn't have an injury designation ahead of Sunday's game against the Patriots.
#2 QB
Mitchell Trubisky: All clear for Week 15
Dec 12th
Trubisky (illness) does not carry an injury designation for Sunday's game against the Patriots.