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Panthers vs Bills Odds, Lines, Spreads & Totals 2025

Bills
26.8 Pts
Panthers
19.8 Pts
Sunday October 26, 2025 at 1:00 PM ET
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BUF
Bills Injury Report
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CAR
Panthers Injury Report
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BUF
Bills Lineup
Inactives
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CAR
Panthers Lineup
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BUF
Bills News
#2 RCB
Maxwell Hairston: Designated for return from IR
Oct 20th
The Bills designated Hairston (knee) for return from injured reserve Monday, Alaina Getzenberg of ESPN.com reports.
#3 WR
Joshua Palmer: Labeled week-to-week
Oct 15th
Bills head coach Sean McDermott said Tuesday that Palmer (ankle) is viewed as week-to-week, Alec White of the team's official site reports.
#2 WLB
Shaq Thompson: Leads Buffalo with 10 stops
Oct 14th
Thompson recorded 10 tackles (five solo) and one pass defense during the Bills' 24-14 loss to the Falcons on Monday.
#2 RDE
Michael Hoecht: Reinstated from suspension
Oct 14th
The NFL lifted Hoecht's six-game suspension Tuesday, Alaina Getzenberg of ESPN.com reports.
#2 LDT
Larry Ogunjobi: Eligible to return to Buffalo
Oct 14th
Ogunjobi's six-game suspension was lifted by the NFL on Tuesday, Alaina Getzenberg of ESPN.com reports.
#1 DT2
DaQuan Jones: Considered week-to-week
Oct 14th
Coach Sean McDermott said Tuesday that Jones (calf) is week-to-week, Maddy Glab of the Bills' official site reports.
#1 MLB
Terrel Bernard: Day-to-day with ankle injury
Oct 14th
Head coach Sean McDermott said Tuesday that Bernard is considered "day-to-day" due to an ankle injury he sustained during the Bills' 24-14 loss to the Falcons on Monday, Maddy Glab of the Bills' official site reports.
#6 WR
Elijah Moore: Mistake-prone Week 6
Oct 14th
Moore failed to catch either of his two targets in Monday night's loss to the Falcons.
#3 RB
Ray Davis: Catches TD in Monday's loss
Oct 14th
Davis caught both of his targets for 19 yards and one touchdown in Monday's 24-14 loss to the Falcons.
#2 RB
Ty Johnson: Accounts for 16 yards in Week 6
Oct 14th
Johnson carried once for five yards and added an 11-yard reception on two targets in Monday's 24-14 loss to the Falcons.
#1 FB
Reggie Gilliam: Logs 21 snaps in Week 6
Oct 14th
Gilliam went without a carry or target while playing 21 of the Bills' 57 offensive snaps in Monday's 24-14 loss to the Falcons.
#5 WR
Tyrell Shavers: Season-high five targets in loss
Oct 14th
Shavers played 28 of the Bills' 57 snaps on offense and finished with three catches for 27 yards on five targets in Monday's 24-14 loss to the Falcons.
#3 TE
Jackson Hawes: Goes without target in Week 6
Oct 14th
Hawes went without a target while playing 31 of the Bills' 57 snaps on offense in Monday's 24-14 loss to the Falcons.
#2 TE
Dawson Knox: Scores TD on one catch
Oct 13th
Knox brought in one of two targets for a 19-yard touchdown in the Bills' 24-14 loss to the Falcons on Monday night.
#1 WR
Keon Coleman: Minimal yardage on three catches
Oct 13th
Coleman brought in three of six targets for 11 yards in the Bills' 24-14 loss to the Falcons on Monday.
#2 WR
Khalil Shakir: Three catches in Week 6 loss
Oct 13th
Shakir brought in three of six targets for 33 yards in the Bills' 24-14 loss to the Falcons on Monday.
#1 RB
James Cook: Solid rushing night in loss
Oct 13th
Cook rushed 17 times for 87 yards and didn't draw a target in the Bills' 24-14 loss to the Falcons on Monday night.
#1 QB
Josh Allen: Rough night in Week 6 loss
Oct 13th
Allen completed 15 of 26 passes for 180 yards with two touchdowns and two interceptions and rushed six times for 42 yards in the Bills' 24-14 loss to the Falcons on Monday night. He also committed two fumbles, neither of which were lost.
#1 K
Matt Prater: Quiet night on MNF
Oct 13th
Prater did not attempt a field goal and went 2-for-2 on extra-point tries in Monday night's 24-14 loss to the Falcons.
#1 FS
Cole Bishop: Returns to action Monday
Oct 13th
Bishop (lower body) has returned to Monday's Week 6 contest versus Atlanta, Alaina Getzenberg of ESPN.com reports.
#4 WR
Curtis Samuel: Won't suit up vs. Falcons
Oct 13th
Samuel (neck/ribs) is inactive for Monday's road game against Atlanta.
#1 TE
Dalton Kincaid: Inactive Monday
Oct 13th
Kincaid (oblique) is inactive for Monday night's game against the Falcons.
#1 LDT
Ed Oliver: Good to go vs Falcons
Oct 11th
Oliver (ankle) has no injury designation for Buffalo's matchup versus the Falcons on Monday.
#3 LDT
T.J. Sanders: Lands on IR
Oct 11th
The Bills placed Sanders (knee) on injured reserve Saturday, Alaina Getzenberg of ESPN reports.
#2 SS
Damar Hamlin: Placed on IR
Oct 11th
The Bills placed on Hamlin (pectoral) on injured reserve Saturday, Alaina Getzenberg of ESPN.com reports.
#1 WLB
Matt Milano: Won't play Monday
Oct 11th
Milano (pectoral) has been ruled out for Buffalo's matchup versus the Falcons on Monday, Alaina Getzenberg of ESPN reports.
#1 SLB
Dorian Williams: Logs full practice Friday
Oct 10th
Williams (knee) practiced in full Friday.
#2 K
Tyler Bass: Practice window not opening yet
Oct 9th
Bills coach Sean McDermott said Thursday that Bass (left hip/groin) is among players on IR who will not have their practice windows opened yet, Joe Buscaglia of The Athletic reports.
CAR
Panthers News
#1 WLB
Nic Scourton: Breaks out vs. Jets
Oct 20th
Scourton tallied two total tackles (one solo), including 1.5 sacks, during Sunday's 13-6 win over the Jets.
#1 RDE
Derrick Brown: Does it all in Week 7
Oct 20th
Brown recorded seven total tackles (four solo), including 2.0 sacks, and three passes defended in Sunday's 13-6 win over the Jets.
#1 RCB
Jaycee Horn: Nabs two picks vs. Jets
Oct 20th
Horn recorded one assisted tackle and two interceptions in Sunday's 13-6 win over the Jets.
#1 QB
Bryce Young: Diagnosed with high-ankle sprain
Oct 20th
Young suffered a high-ankle sprain in Sunday's win over the Jets and is expected to miss at least a Week 8 contest against the Bills, Tom Pelissero of NFL Network reports.
#2 QB
Andy Dalton: Looks set for stint as starter
Oct 20th
Dalton is expected to start Sunday's game against the Bills, and potentially longer, after Bryce Young suffered a high-ankle sprain Week 7, Tom Pelissero of NFL Network reports.
#2 WR
Xavier Legette: Career day in win
Oct 19th
Legette caught nine of 11 targets for 92 yards and a touchdown in Sunday's 13-6 win over the Jets.
#1 K
Ryan Fitzgerald: Makes two FGAs in win
Oct 19th
Fitzgerald made both of his field-goal attempts and an extra-point try in Sunday's 13-6 win over the Jets.
#4 WR
Jimmy Horn: Smaller workload in Week 7
Oct 19th
Horn caught one of two targets for eight yards and rushed once for seven yards in Sunday's 13-6 win over the Jets.
#3 WR
Jalen Coker: No catches Sunday
Oct 19th
Coker was targeted twice but didn't record a catch in Sunday's 13-6 win over the Jets.
#1 TE
Ja'Tavion Sanders: Blanks in return
Oct 19th
Sanders was targeted twice but didn't record a catch in Sunday's 13-6 win over the Jets.
#2 TE
Tommy Tremble: Struggles in Week 7
Oct 19th
Tremble caught his only target for no yards in Sunday's 13-6 win over the Jets.
#1 WR
Tetairoa McMillan: Overshadowed by Legette
Oct 19th
McMillan recorded three receptions on five targets for 33 yards in Sunday's 13-6 win over the Jets.
#2 RB
Rico Dowdle: Alternates possessions with Hubbard
Oct 19th
Dowdle rushed the ball 17 times for 79 yards in Sunday's 13-6 win over the Jets. He added one reception on two targets for 17 yards.
#1 RB
Chuba Hubbard: Even split with Dowdle
Oct 19th
Hubbard recorded 14 rushes for 31 yards in Sunday's 13-6 win over the Jets. He added two receptions on three targets for 24 yards.
#2 SLB
Princely Umanmielen: Returns to game
Oct 19th
Umanmielen (back) has returned to Sunday's contest against the Jets, Sheena Quick of Fox Sports Radio 1340 reports.
#1 LG
Damien Lewis: Won't play Week 7
Oct 19th
Lewis (shoulder) is inactive for Sunday's game against the Jets, Darin Gantt of the Panthers' official site reports.
#1 LDE
Tershawn Wharton: Good to go Week 7
Oct 19th
Wharton (toe) is active for Sunday's game against the Jets, Darin Gantt of the Panthers' official site reports.
#1 RT
Taylor Moton: Will play Week 7
Oct 19th
Moton (elbow) is active for Sunday's game against the Jets, Darin Gantt of the Panthers' official site reports.
#1 C
Austin Corbett: Cleared to play Week 7
Oct 19th
Corbett (knee) is active for Sunday's game against the Jets, Darin Gantt of the Panthers' official site reports.
#6 WR
Hunter Renfrow: Inactive Sunday
Oct 19th
Renfrow (coach's decision) is inactive for Sunday's game against the Jets, Darin Gantt of the Panthers' official site reports.
#3 WLB
Patrick Jones: Officially placed on IR
Oct 18th
Jones (back) was placed on injured reserve Saturday, Joe Person of The Athletic reports.
#2 LCB
Akayleb Evans: Ready for Sunday
Oct 17th
Evans (hamstring) has no injury designation ahead of Sunday's matchup against the Jets.
#1 LILB
Christian Rozeboom: Leading tackler in win
Oct 14th
Rozeboom logged six tackles (three solo) in the Panthers' win over the Cowboys on Sunday.
#4 TE
James Mitchell: Held catchless in Week 6
Oct 14th
Mitchell didn't draw a target while playing 10 of the Panthers' 67 snaps on offense in Sunday's 30-27 win over the Cowboys.
#3 TE
Mitchell Evans: Nabs 21-yard reception
Oct 14th
Evans played 39 of the Panthers' 67 snaps on offense and hauled in a 21-yard reception on his lone target in Sunday's 30-27 win over the Cowboys.
#4 RB
DeeJay Dallas: Gets first carry with Carolina
Oct 14th
Dallas carried once for zero yards and returned one kickoff for 28 yards in Sunday's 30-27 win over the Cowboys.
#5 WR
Brycen Tremayne: Blanked on stat sheet in Week 6
Oct 14th
Tremayne failed to draw a target while playing 23 of the Panthers' 67 snaps on offense in Sunday's 30-27 win over the Cowboys.
#3 RB
Trevor Etienne: Efficient during win
Oct 12th
Etienne rushed three times for 17 yards during Sunday's 30-27 win over the Cowboys.
#1 SCB
Chau Smith-Wade: Cleared to play Week 6
Oct 12th
Smith-Wade (chest) is active for Sunday's game against the Cowboys, Darin Gantt of the Panthers' official site reports.
#1 LCB
Mike Jackson: Good to go against Dallas
Oct 12th
Jackson (ribs) is active for Sunday's game against the Cowboys, Darin Gantt of the Panthers' official site reports.
#1 SS
Tre'von Moehrig: Productive in win
Oct 7th
Moehrig logged seven tackles (six solo) in the Panthers' win over the Dolphins on Sunday.