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Chargers vs Colts Odds, Lines, Spreads & Totals 2025

Colts
23.0 Pts
Chargers
25.5 Pts
Sunday October 19, 2025 at 4:05 PM ET
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Colts Lineup
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Colts News
#7 WR
Laquon Treadwell: Elevated for first time
Oct 18th
The Colts elevated Treadwell to the active roster from the practice squad Saturday.
#4 RB
Ameer Abdullah: Joins active roster
Oct 18th
The Colts signed Adbullah from the practice squad to the active roster Saturday.
#3 LCB
Charvarius Ward: Placed on IR
Oct 18th
Ward (concussion) was placed on injured reserve Saturday.
#3 RB
Tyler Goodson: Won't face Chargers
Oct 18th
Goodson (groin) has been ruled out ahead of Sunday's game against the Chargers.
#1 SCB
Kenny Moore: Expected to play Week 7
Oct 17th
Moore (Achilles/rest) is listed as questionable for Sunday's game against the Chargers.
#5 WR
Adonai Mitchell: Chance at redemption Week 7
Oct 17th
Mitchell, who was inactive for the Colts' Week 6 win over the Cardinals, will play Sunday against the Chargers, while Indianapolis will be without Josh Downs (concussion) and Ashton Dulin (chest), James Boyd of The Athletic reports.
#2 WR
Josh Downs: Won't play Sunday
Oct 17th
Downs (concussion) has been ruled out for Sunday's game against the Chargers.
#4 WR
Ashton Dulin: Won't play in Week 7
Oct 17th
Dulin (chest) has been ruled out for Sunday's game against the Chargers, Amanda Foster of the Colts' official site reports.
#2 QB
Riley Leonard: Stepping in as No. 2 quarterback
Oct 15th
Leonard appears in line to serve as the top backup to starting quarterback Daniel Jones for a second straight game Sunday against the Chargers after the Colts placed Anthony Richardson (orbital) on injured reserve Monday, Stephen Holder of ESPN.com reports.
#1 MLB
Zaire Franklin: Racks up nine stops Sunday
Oct 14th
Franklin posted nine tackles (six solo) in Sunday's 31-27 win over the Cardinals.
#1 SS
Nick Cross: Produces five stops in Week 6
Oct 14th
Cross finished Sunday's 31-27 win over Arizona with five tackles (four solo).
#1 LCB
Mekhi Blackmon: Nabs interception in Week 6 win
Oct 14th
Blackmon tallied five tackles (four solo) and two defensed passes, including an interception, in Sunday's 31-27 victory versus the Cardinals.
#1 WLB
Germaine Pratt: Paces team in tackles in debut
Oct 14th
Pratt tallied 11 tackles (eight solo) in Sunday's 31-27 Week 6 win over Arizona.
#3 SS
Reuben Lowery: Claimed by Colts
Oct 13th
Indianapolis claimed Lowery off waivers from the Ravens on Monday.
#3 QB
Anthony Richardson: Sent to injured reserve
Oct 13th
The Colts placed Richardson (orbital) on injured reserve Monday.
#1 LDE
Kwity Paye: Records 2.0 sacks in win
Oct 13th
Paye had 2.0 sacks, three total QB hits and seven total tackles in Sunday's win over Arizona.
#2 RB
DJ Giddens: Just two snaps on offense
Oct 13th
Giddens did not have a carry nor was targeted in the passing game in Sunday's win over Arizona. He played just two snaps on offense.
#1 K
Michael Badgley: Perfect in season debut
Oct 12th
Badgley made his only field-goal attempt and went 4-for-4 on PATs in Sunday's 31-27 win over the Cardinals.
#3 WR
Alec Pierce: Two catches in return
Oct 12th
Pierce brought in two of four targets for 48 yards in the Colts' 31-27 win over the Cardinals on Sunday.
#1 WR
Michael Pittman: Two catches in Week 6 win
Oct 12th
Pittman brought in two of three targets for 20 yards in the Colts' 31-27 win over the Cardinals on Sunday.
#1 QB
Daniel Jones: Multiple TDs in close win
Oct 12th
Jones completed 22 of 30 passes for 212 yards with two touchdowns and one interception while adding five carries for 20 yards and another score in the Colts' 31-27 win over the Cardinals on Sunday.
#1 TE
Tyler Warren: Paces air attack in win
Oct 12th
Warren secured six of nine targets for 63 yards and a touchdown in the Colts' 31-27 win over the Cardinals on Sunday.
#1 RB
Jonathan Taylor: Another 100-yard effort Sunday
Oct 12th
Taylor rushed 21 times for 123 yards and a touchdown while securing all four targets for 14 yards in the Colts' 31-27 win over the Cardinals on Sunday.
#1 LDT
Grover Stewart: Looking good for Week 6
Oct 8th
Stewart (biceps) was a full participant at practice Wednesday.
#1 RDE
Laiatu Latu: Gets another interception Sunday
Oct 7th
Latu recorded one tackle (one solo) and an interception during Sunday's 40-6 win versus the Raiders.
#1 DT2
DeForest Buckner: Gets first sack of season
Oct 7th
Buckner recorded six tackles (two solo) including 1.0 sacks during Sunday's 40-6 win versus the Raiders.
#2 K
Spencer Shrader: Heads to IR
Oct 7th
The Colts placed Shrader (knee) on injured reserve Tuesday, Amanda Foster of the Colts' official site reports.
#2 LDE
Tyquan Lewis: Good to go against Las Vegas
Oct 5th
Lewis (oblique) is active for Sunday's game against the Raiders, James Boyd of The Athletic reports.
LAC
Chargers News
#3 RB
Nyheim Hines: Elevated for Week 7
Oct 18th
The Chargers elevated Hines from the practice squad to the active roster Saturday.
#1 RILB
Denzel Perryman: Activated from injured reserve
Oct 18th
The Chargers activated Perryman (ankle) from injured reserve Saturday.
#1 ROLB
Khalil Mack: Off IR, remains questionable
Oct 18th
The Chargers activated Mack (elbow) from injured reserve Saturday, but he's still listed as questionable for Sunday's contest against the Colts.
#1 LT
Joe Alt: Likely to miss third straight game
Oct 17th
Alt (ankle) is doubtful for Sunday's game against the Colts.
#2 LT
Jamaree Salyer: Gets tagged as questionable
Oct 17th
Salyer (knee) is listed as questionable for Sunday's game versus the Colts, Daniel Popper of The Athletic reports.
#2 RG
Jamaree Salyer: Gets tagged as questionable
Oct 17th
Salyer (knee) is listed as questionable for Sunday's game versus the Colts, Daniel Popper of The Athletic reports.
#1 RT
Trey Pipkins: Out against Colts
Oct 17th
Pipkins (knee) has been ruled out ahead of Sunday's game against the Colts.
#1 LILB
Daiyan Henley: Good to go against Indianapolis
Oct 17th
Henley (groin) does not carry an injury designation into Sunday's game against the Colts, Eric Smith of the Chargers' official site reports.
#2 RILB
Troy Dye: Questionable to play Week 7
Oct 17th
Dye (thumb) is listed as questionable for Sunday's game against the Colts, Eric Smith of the Chargers' official site reports.
#5 WR
Derius Davis: Could play vs. Indianapolis
Oct 17th
Davis (knee) is listed as questionable for Sunday's game against the Colts, Eric Smith of the Chargers' official site reports.
#1 FS
Elijah Molden: Unlikely to play vs. Indianapolis
Oct 17th
Molden (thumb) is listed as doubtful for Sunday's game against the Colts.
#2 RB
Hassan Haskins: Questionable after full practice
Oct 17th
Haskins (chest) is listed as questionable for Sunday's game against the Colts after practicing fully Friday.
#1 SS
Derwin James: Upgrades to full practice Thursday
Oct 16th
James (wrist) was a full participant in Thursday's practice.
#2 WR
Quentin Johnston: Practices fully Thursday
Oct 16th
Johnston (hamstring) practiced fully Thursday.
#1 FB
Scott Matlock: Returns to practice Wednesday
Oct 15th
Matlock (personal) practiced in full Wednesday.
#4 TE
Tyler Conklin: Snap count plummets vs. Miami
Oct 14th
Conklin did not register a target during the Chargers' 29-27 win over the Dolphins on Sunday.
#2 TE
Will Dissly: Two catches in return
Oct 14th
Dissly finished Sunday's 29-27 win over the Dolphins with two catches on as many targets for 18 yards.
#4 WR
Tre' Harris: Extended playing time sans Johnston
Oct 14th
Harris caught four passes on five targets for 27 yards during the Chargers' 29-27 win over the Dolphins on Sunday.
#1 K
Cameron Dicker: Busy day in Week 6 win
Oct 12th
Dicker made all five of his field-goal attempts and both of his extra-point tries during the Chargers' 29-27 win over the Dolphins on Sunday.
#1 TE
Oronde Gadsden: Career high in receptions
Oct 12th
Gadsden caught seven of his eight targets for 68 yards in the 29-27 win over the Dolphins.
#1 WR
Ladd McConkey: Catch-and-run crucial in win
Oct 12th
McConkey caught seven of his nine targets for 100 yards and a touchdown in the 29-27 win over the Dolphins on Sunday.
#1 QB
Justin Herbert: Sterling effort in win
Oct 12th
Herbert completed 29 of his 38 pass attempts for 264 yards and two touchdowns in the 29-27 win over the Dolphins on Sunday.
#1 RB
Kimani Vidal: Emerges as lead back in win
Oct 12th
Vidal carried the ball 18 times for 124 yards and also caught three of his four targets for 14 yards and a touchdown in the 29-27 win over the Dolphins on Sunday.
#4 RB
Omarion Hampton: Likely to miss more than four games
Oct 12th
Hampton, who was placed on injured reserve Wednesday due to a left ankle injury, isn't expected to be out for the season but is on track to be sidelined for more than the four-game minimum, Mike Garafolo of NFL Network reports.
#2 RT
Bobby Hart: Signed to Bolts' active roster
Oct 11th
The Chargers signed Hart from the practice squad to the active roster Saturday, Kris Rhim of ESPN.com reports.
#3 LDE
Da'Shawn Hand: Moved to injured reserve
Oct 11th
The Chargers placed Hand (groin) on injured reserve Saturday.
#1 RG
Mekhi Becton: All set for Week 6
Oct 9th
Becton (hand) was a full participant at practice Thursday.
#1 LOLB
Tuli Tuipulotu: Silent in Sunday's loss
Oct 7th
Tuipulotu did not record any stats in 48 defensive snaps and two special teams snaps during Sunday's 27-10 loss versus the Commanders.
#2 ROLB
Odafe Oweh: Dealt to Bolts
Oct 7th
The Chargers acquired Oweh and a 2027 seventh-round pick from the Ravens on Tuesday in exchange for safety Alohi Gilman and a 2026 fifth-round pick, Adam Schefter of ESPN reports.
#3 WR
Keenan Allen: Leading receiver on nine targets
Oct 5th
Allen brought in five of nine targets for 58 yards in Sunday's 27-10 loss to Washington.
#3 TE
Tucker Fisk: Will play against Washington
Oct 5th
Fisk (toe) is active for Sunday's game against the Commanders.