San Francisco 49ers Odds For 2025 | +2200 Super Bowl Odds

WR

Brandon Aiyuk: Done for 2025

Dec 13th

The 49ers placed Aiyuk (knee) on the reserve/left squad list Saturday, Matt Barrows of The Athletic reports.

RB

Christian McCaffrey: Expected to play vs. Tennessee

Dec 13th

Although he was added to the 49ers' injury report Saturday, McCaffrey (back) is expected to play against the Titans on Sunday, Adam Schefter of ESPN reports.

RB

Christian McCaffrey: Now questionable for Week 15

Dec 13th

McCaffrey has been added to the 49ers' injury report due to a back injury, and he is listed as questionable for Sunday's game against the Titans, Matt Barrows of The Athletic reports.

QB

Kurtis Rourke: Won't be available Sunday

Dec 12th

Rourke (knee) is out for Sunday's game versus the Titans, Cam Inman of The San Jose Mercury News reports.

LB

Nick Martin: Won't play vs. Titans

Dec 12th

Martin (concussion) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports.

DE

Yetur Gross-Matos: Won't suit up vs. Titans

Dec 12th

Gross-Matos (hamstring) is out for Sunday's game versus Tennessee, Cam Inman of The San Jose Mercury News reports.

LB

Tatum Bethune: Missing another game

Dec 12th

Bethune (ankle) has been ruled out for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.

DE

Sam Okuayinonu: Won't play Week 15

Dec 12th

Okuayinonu (ankle) has been ruled out for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.

FB

Kyle Juszczyk: Cleared to play Week 15

Dec 12th

Juszczyk (ribs) does not have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.

RB

Christian McCaffrey: Cleared after full practice

Dec 12th

McCaffrey (illness) doesn't have an injury designation for Sunday's game against the Titans, Cam Inman of The San Jose Mercury News reports.