Monday Night Football Picks: Arizona Cardinals vs. San Francisco 49ers Betting Odds, Best Bets and Predictions

Monday Night Football Picks: Arizona Cardinals vs. San Francisco 49ers Betting Odds, Best Bets and Predictions

This article is part of our NFL Picks series.

Monday Night Football Bets and Player Props for Cardinals vs. 49ers

Last article: 4-7, -3.43 units 

Season: 65-92, -35.97 units

We have good news for Maryland residents as sports betting is set to go live this week. Get ahead of the action and be ready for launch with the BetMGM Maryland Bonus Code, which gets new users a $200 registration bonus. 

Arizona Cardinals vs. San Francisco 49ers Betting Odds for Week 11

Spread: 49ers -10, -110 (DraftKings)

Total: 43.0, -110 (DraftKings)

Moneyline: 49ers -475, Cardinals +380

Maryland residents can get ready for sports betting launching this week with the DraftKings Maryland Promo Code. Ohio is next in line to launch, so residents in the Buckeye State can get in on the action with the DraftKings Ohio Promo Code.

Arizona Cardinals vs. San Francisco 49ers Player Props

Rondale Moore over 59.5 receiving yards, -115 (DraftKings)

Moore has really taken off over the last few weeks, following his return to good health from an early-season hamstring injury. And speaking of hamstrings, Cardinals WR1 DeAndre Hopkins was limited in practice this week with a hamstring injury, so it's possible that Moore might even see a little extra work tonight. It's also notable that Moore turned in his best game of the season last week with backup QB Colt McCoy at the controls, and it appears McCoy will be getting another start tonight, which could in turn help Moore once again. There's also a strong likelihood of a positive game script, with the Cardinals likely to be playing from behind.

Rondale Moore over 6.5 receptions, +120 (DraftKings)

Moore has covered this total in three straight games, while averaging 10 targets per game over that span. He topped out at 13 targets last week with Colt McCoy at QB, and in addition to the Hopkins injury status listed above, we should also take note that Cardinals TE Zach Ertz will miss this game, replaced by rookie TE Trey McBride, who has been a complete non-factor so far this year. That could lead to even more targets for the Cardinals slot receiver. There's just a lot working in Moore's favor tonight.

Rondale Moore anytime touchdown, +340 (DraftKings)

Moore only has one touchdown so far this year, but he's either been limited or missed several games, and there's no question that he'll be highly active tonight. This is a generous number on one of the top receiving threats for the Cardinals.

Christian McCaffrey over 36.5 receiving yards, -115 (DraftKings)

McCaffrey has collected 15 targets over the last two games, as his role in the offense solidifies following his low-usage 49ers debut a few weeks ago. It's also notable that Elijah Mitchell saw heavy usage in the running game last week (in his first game back from injury, no less), which seems to indicate the 49ers are more interested in using CMC as a receiver.

Brandon Aiyuk over 54.5 receiving yards, -115 (DraftKings)

I had some concerns that McCaffrey's arrival might impact Aiyuk's role in the receiving game, but that hasn't seemed to be the case thus far, with Aiyuk now having covered the total in five straight games, and covering it by nearly 30 yards in each of his last for games. As noted previously, Aiyuk excels at recording long gainers, now having logged a 20+ yard reception in 7-of-9 games this year, and with the 49ers having so many different weapons on offense, that seems likely to continue. Hard not to like this number based on Aiyuk's recent results, combined with his consistent ability to produce big plays.

If you're in Maryland, you can sign up at Caesars Sportsbook with the Caesars Sportsbook Maryland Promo Code to get $100 in free bets. 

RotoWire has everything you need to enjoy your NFL betting experience, including the latest NFL odds to weekly NFL picks. We also have up-to-date NFL futures and NFL player futures. Check out our selection of  NFL betting sites and betting promos to see the best deals in your area.

RotoWire Community
Join Our Subscriber-Only NFL Chat
Chat with our writers and other RotoWire NFL fans for all the pre-game info and in-game banter.
Join The Discussion
ABOUT THE AUTHOR
Walter Hand
Walter is a former Las Vegas oddsmaker, and longtime successful fantasy player in both football and baseball.
Will Bill O’Brien Help The Patriots Super Bowl Odds In 2023?
Will Bill O’Brien Help The Patriots Super Bowl Odds In 2023?
What Offseason Changes Will Mean For 2023 Patriots Super Bowl Odds
What Offseason Changes Will Mean For 2023 Patriots Super Bowl Odds
Early Look At Super Bowl 57 Spreads, Totals, And Moneylines
Early Look At Super Bowl 57 Spreads, Totals, And Moneylines
Target Breakdown: 2022 Season in Review for NFL Wide Receivers
Target Breakdown: 2022 Season in Review for NFL Wide Receivers
Dynasty Watch: Olamide Zaccheaus Free Agency
Dynasty Watch: Olamide Zaccheaus Free Agency
NFL Reactions: Conference Championship Weekend
NFL Reactions: Conference Championship Weekend