This article is part of our NFL Picks series.
NFL Picks: Seattle Seahawks vs. San Francisco 49ers Expert Bets and Player Props for Wild Card Weekend
The NFL opens the playoffs Saturday afternoon with a matchup between the Seattle Seahawks and the San Francisco 49ers. Let's try to start the betting week off on the right foot with the following wagers to consider.
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Seattle Seahawks 
vs. San Francisco 49ers 
Betting Odds: Spread, Moneyline, and Total
Seahawks: Spread +9.5 (-105), Moneyline +400
49ers: Spread -9.5 (-115), Moneyline -500
Game Total: 42.0 points
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Wild Card Weekend Picks: Seahawks vs. 49ers Best Bets and Player Props
San Francisco 49ers -5.5 1H (-115 DraftKings Sportsbook) for 2 units
The 49ers come into this game on a 10-game winning streak and beat the Seahawks in both of their meetings (27-7, 21-13). Seattle has been an up-and-down team going 6-4 in their first 10 games, but finishing 3-5, but closed with two wins in a row to get into the playoffs.
This is just a bad matchup for the Seahawks who are 30th in rushing defense while the 49ers are 8th in rushing offense. The 49ers are the best defense in the NFL, ranking 1st in yards allowed, 2nd in rushing yards allowed and 1st in points allowed.
The 49ers will establish their running game and defense in the first half at home as in the first two meetings they outscored the Seahawks 20-0 and 14-3. First half point spread bets avoid the potential of a back door cover which is definitely a possibility here.
Christian McCaffrey Over 16.5 Rushing Attempts (-105 DraftKings Sportsbook) for 1.5 units
McCaffrey had 26 rushing attempts in their last matchup on December 15th in which the 49ers won 21-13. They had Jeffrey Wilson run 18 times and Tyrion Davis-Price 14 times in the first game (27-7).
The 49ers outrushed the Seahawks in attempts 89-28 combined in both games. This screams game script as they can just run the ball and control the game with their defense at home.
Kenneth Walker Under 16.5 Rushing Attempts (-125 DraftKings Sportsbook) for 1 unit
If you buy into the results from the first two games, this is an easy play. Walker had 12 rushing attempts in the December 15th game and only four in the first game. The reason this number is a tad high is over the last three games, Walker has 29, 23, and 26 rushing attempts. But Walker's rushing attempts were always high when the Seahawks won, vs. when they lost (4,3,8,10,14,12,26).
Seahawks vs. 49ers Best Bets Recap
San Francisco 49ers -5.5 1H (-115 DraftKings Sportsbook) for 2 units
Christian McCaffrey Over 16.5 Rushing Attempts (-105 DraftKings Sportsbook) for 1.5 units
Kenneth Walker Under 16.5 Rushing Attempts (-125 DraftKings Sportsbook) for 1 unit
