Champions League Best Bets: Picks, Odds & Predictions for Tuesday, Oct. 21

Champions League best bets for Tuesday, Oct. 21 include Napoli vs PSV, Benfica vs Newcastle, Dortmund vs Copenhagen and Inter Milan vs Union SG.
Champions League Best Bets: Picks, Odds & Predictions for Tuesday, Oct. 21
SPECIAL OFFER

Get 10% OFF

Get 10% off any subscription when you subscribe today. Take advantage of our tools and personalized news for the best sports experience. Use promo code RW10.
PROMO CODE RW10

Champions League Best Bets for Tuesday, October 21: Picks & Predictions

Tuesday's nine-match Champions League slate features several marquee fixtures with betting value across Europe. Napoli travel to PSV Eindhoven in search of a bounce-back win, while Newcastle host Benfica in what could be a wide-open affair. 

We've highlighted four of our favorite bets for Tuesday's action, including value plays for Dortmund at Copenhagen and Inter Milan's trip to Union SG.

Knowing injuries and predicted lineups (and eventually confirmed) for Champions League matches is always useful before betting matches. Check out our lineups page to get all the info.

Match Bet Odds
PSV Eindhoven vs. Napoli Napoli to Win +129
Newcastle United vs. Benfica Both Teams to Score -129
Copenhagen vs. Borussia Dortmund Over 2.5 Goals & Both Teams to Score (SGP) +102
Union SG vs. Inter Milan Under 2.5 Total Goals +114

UEFA Champions League Best Bets for Napoli at PSV Eindhoven

Napoli to beat PSV +129

PSV Eindhoven's Champions League campaign has been disappointing with a single point from two matches, although they showed some positive signs in their comeback draw against Bayer Leverkusen. They enter this game on a good run of form thanks to a five-game undefeated streak in all competitions (W3, D2).

The reigning Serie A champions suffered a 2-0 away loss at Manchester City in their previous UCL contest and a 1-0 defeat at Torino in their last Serie A match. Having won just three of their previous six in all competitions (W3, L3), look for the Serie A giants to shake off their recent woes with a win here.

UEFA Champions League BTTS bet for Benfica at Newcastle United

Both Newcastle & Benfica to score -129

Newcastle United enter Champions League play after a domestic loss for the second time in a row, hoping to repeat their 4-0 trouncing win of USG from the second matchday. Benfica represent a tougher assignment, and have the talent to give Newcastle trouble. The Magpies have won three of their last five matches at home this season (W3, L2), and both losses have come against top opponents in Barcelona and Arsenal.

Benfica have scored at least one goal in all but two of their previous 11 competitive matches, so they're a good bet to find the back of the net at least once here. Don't be surprised if both teams score, as that has happened in four of Newcastle's last seven games in all competitions.

UEFA Champions League SGP for Borussia Dortmund at Copenhagen

SGP: Over 2.5 total goals & both teams to score +102

FC Copenhagen have yet to win in the Champions League this season (D1, L1), but their matches have been entertaining. They drew 2-2 against Bayer Leverkusen after squandering the lead twice and losing to Qarabag 2-0 despite leading in possession (51-49) and shots (12-10). The Danish side are on a three-game winless run (D1, L2).

Dortmund have lost just one competitive match at home this season (W4, D4, L1) and five of the previous seven have featured both clubs scoring. Furthermore, their two contests in Europe have also finished over 4.5 total goals. Thus, the possibility of another high-scoring matchup is certainly on the table since both teams are far more accomplished going forward than defending. 

Inter Milan at Royale Union SG Betting Odds & Best Bet

Under 2.5 goals between Inter and USG +114

Union Royale SG suffered a disappointing 4-0 loss to Newcastle United in their second Champions League match, erasing the good will earned by their 3-1 win over PSV Eindhoven to open the league stage. Five of their last nine matches across all competitions have had under 2.5 total goals, and it wouldn't be shocking to see that happen here. Considering all the struggles Royale Union showed against Newcastle, it's hard to see them performing much better against Inter Milan, even if they'll be at home.

Inter Milan are coming off a 1-0 win over AS Roma the last time out, and Inter have won three of their last four matches in all competitions without conceding a goal. They also kept a clean sheet in their Champions League opener, a 2-0 road win over Ajax, so Christian Chivu's men have showed the ability to deliver stout defensive performances at the European stage. Inter have conceded under 1.5 goals in each of their previous six competitive games, further enhancing the possibility of another low-scoring contest.

Champions League Betting Picks Tuesday, October 21

  • PSV Eindhoven vs. Napoli: Napoli to win +129
  • Newcastle United vs. Benfica: Both teams to score -129
  • FC Copenhagen vs. Dortmund SGP: Both teams to score and over 2.5 total goals +102
  • Union Royale SG vs. Inter Milan: Under 2.5 total goals +114

Champions League Betting FAQ

Who are the best Champions League bets for Oct. 21?
Our top picks are Napoli to beat PSV, both teams to score in Newcastle vs. Benfica, over 2.5 goals and BTTS in Dortmund vs. Copenhagen, and under 2.5 in Inter vs. Union SG.

What time do Champions League matches start Tuesday?
Most fixtures kick off at 3 p.m. ET, with select early matches beginning at 12:45 p.m. ET.

Where can I compare Champions League odds?
Check our Champions League odds page for live lines from DraftKings, FanDuel, BetMGM and more.

Visit RotoWire all season for exclusive sports betting picks and our weekly Premier League betting show. Remember that betting apps vary in terms of odds, so we have an easy-to-use odds page that allows you to shop for the best lines at DraftKings, FanDuel, BetMGM and PointsBet. Claim over a thousand dollars in bonuses by signing up at the best sports betting sites using the best sportsbook promos.

ABOUT THE AUTHOR
35-year-old sports analyst and journalist. Fan of every single sport on this earth, but mainly NBA, MLB, NFL, NHL and soccer. Eternal optimistic who, for unknown reasons, chose to root for the Chicago Cubs and Jacksonville Jaguars. Born and raised in Chile.
RotoWire Logo

Continue the Conversation

Join the RotoWire Discord group to hear from our experts and other Soccer fans.

Top News

Tools

NFL Draft Kit Logo

NFL Draft Kit

Fantasy Tools

Don’t miss a beat. Check out our 2025 NFL Fantasy Football rankings.