There was no shortage of big, fantasy-relevant injury news this Friday, and that's on top of three starting QB changes earlier in the week (Mike White, Sam Darnold, Kyle Allen). A fourth team, the Rams, declined to name its Week 12 starter after Friday's practice, though most signs point to Bryce Perkins after he took first-team reps throughout the week. That said, John Wolford isn't listed on the final injury report, nor is fellow NFC West quarterback Kyler Murray.
The bottom section here — labelled 'truly questionable' — can be used as a checklist/cheatsheet for Sunday morning and afternoon when inactive lists come out. First, let's see who's definitely in and who's definitely out...
Good to Go 💯
QB Kyler Murray (hamstring)
QB John Wolford (neck) 
RB Aaron Jones (shin) + WRs Allen Lazard (shoulder) & Randall Cobb (illness) + TE Robert Tonyan (illness)
WR A.J. Brown (illness)
WR JuJu Smith-Schuster (concussion)
WR Corey Davis
Sean McVay says "you'll see on Sunday" whether QB Bryce Perkins starts.
— Jourdan Rodrigue (@JourdanRodrigue) November 25, 2022
However, he also confirms that Perkins has gotten the No. 1 reps this week. John Wolford has been limited this week (neck).
A.J. Brown is dealing with a pretty serious stomach bug.
He said he had a "terrible" Thanksgiving because he spent the whole day in bed.
Asked how he's feeling on a scale of 1-10, Brown said he feeling like a 3 right now. Brown adds he hasn't ate anything all day. pic.twitter.com/3nIQy2yCQq
— Josh Tolentino (@JCTSports) November 25, 2022
Ruled Out/Doubtful 🚑
- QB Matthew Stafford (neck)
RB Raheem Mostert (D - knee)
RB Leonard Fournette (D - hip)
RB Joe Mixon (concussion)- RB Clyde Edwards-Helaire (IR - ankle)
WR Mike Williams (ankle)
WRs Jerry Jeudy (ankle) & KJ Hamler (hamstring)- WR Rondale Moore (groin)
- WRs Kadarius Toney (hamstring) + Mecole Hardman (IR - groin)
- WR Russell Gage (hamstring)
WR Dee Eskridge (hand)- WR Romeo Doubs (ankle)
WR Hunter Renfrow (IR - oblique) + TE Darren Waller (IR - hamstring)
Lotta RB value on DraftKings this week with Leonard Fournette and Raheem Mostert likely out. The obvious ones, imo:
Kenneth Walker - $6900 vs LV
Jeff Wilson - $5900 vs MIA
Rachaad White - $5100 at CLESome Pivots
James Conner $6600
— Jerry 🦃 (@JerryDonabedian) November 25, 2022
Antonio Gibson $5400
Latavis Murray $5000
Key Defensive Players + Offensive Linemen
CB Greg Newsome (concussion)
LT Ronnie Stanley (ankle)
CB Derek Stingley (hamstring)
S Jaquan Brisker (concussion) + CB Kyler Gordon (concussion)
DL/OLB Denico Autry (knee)- CB Kristian Fulton (hamstring) + C Ben Jones (concussion)
CB Benjamin St-Juste (ankle)- CB Byron Murphy (back) + OT D.J. Humphries (back)
- C Brian Allen (thumb)
- LB De'Vondre Campbell (knee)
Listed as Questionable - Should Play 👍
- RB Gus Edwards (hamstring) - 1:00 ET
WR Terrace Marshall (shoulder) - 1 ET- TE Logan Thomas (ribs/illness) - 1 ET
- DL Jeffery Simmons (ankle) - 1 ET
Gus Edwards: "I feel good, man. Had a good week of progress, definitely made a lot of progress. I'm excited to see what happens."
— Ryan Mink (@ryanmink) November 25, 2022
Truly Questionable 🤔
Early Games
- QB Justin Fields (shoulder)
- WR Ja'Marr Chase (hip)
- WRs Devin Duvernay (hamstring) & Demarcus Robinson (hip) + TE Isaiah Likely (ankle)
RB Caleb Huntley (ankle)
Duvernay and Likely were end-of-week additions to the injury report, listed as questionable after limited practices Friday. Robinson, on the other hand, missed practice Friday before being a full participant Friday, i.e., he should be able to play. James Proche and DeSean Jackson (hamstring) could run more routes if Duvernay is out (Jackson is on the practice squad but reportedly was able to practice this week).
#Bears HC Matt Eberflus on QB Justin Fields: "Justin's status is the same. We've got 48 hours to assess that."
— Larry Mayer (@LarryMayer) November 25, 2022
Zac Taylor on Ja'Marr Chase: "He's easy to communicate with. For me to let him know my thinking over the week and get a feel for where he's at. He's honest, which is good. We have guys that will tell you the truth, so you don't have to feel out what does he really mean."
— Charlie Goldsmith (@CharlieG__) November 25, 2022
Late Afternoon
- RB Josh Jacobs (calf) - 4:05
- WRs Marquise Brown (IR - foot) & Greg Dortch (thumb) - 4:05
- WR Allen Robinson (ankle) + TE Tyler Higbee (knee) - 4:25
WR Deebo Samuel (hamstring) - 4:25
RB Mark Ingram (knee) - 4:25
Zamir White could get his first chance in the lead role if Jacobs is out, with Ameer Abdullah and Brandon Bolden also candidates to pick up some snaps (but mostly on passing downs, presumably).
For the Cardinals, it's unclear who will take WR snaps besides DeAndre Hopkins, as coach Kliff Kingsbury said earlier this week that Brown will be on a "pitch count" if he plays. Rondale Moore (groin) is already ruled out, and A.J. Green worked ahead of Robbie Anderson last week when the Cards were pressed for depth.
For Robinson and Higbee, I don't really have a read apart from not wanting to roster either of them anyway. The Rams are a mess at QB and along the O-line, and neither Robinson nor Higbee looks like the two-years-ago version of himself.
Deebo seems healthy enough to play, but I'm putting him in this section because the Niners don't necessarily need him this week and might be worried about the hamstring injury lingering (or worsening) if he doesn't rest. Upgrade Brandon Aiyuk and George Kittle (and Jauan Jennings!) if there's word of Samuel being limited or absent Sunday afternoon.
Spoke to @Raiders RB Josh Jacobs in the locker room & wished him well in SEA. After being a full participant in practice was "limited" today due to a calf injury. I noticed the slight limp inside the locker room but he was walking on it. Hopefully he plays, listed "Questionable."
— Ryan Sakamoto (@BEASTwriter) November 25, 2022
Primetime
RB Jaylen Warren (hamstring) - MNF
Key Defensive Players + O-Linemen
- DT Vita Vea (foot) - 1 ET
- K Randy Bullock (calf) - 1 ET
- DE Chase Young (knee) - 1 ET
- LT Kolton Miller (shoulder) - 4:05 ET
- S Juan Thornhill (calf) + G Joe Thuney (ankle) - 4:25 ET
- CB Marshon Lattimore (abs) + DEs Marcus Davenport (calf) & Cameron Jordan (eye)
- Ahkello Witherspoon (hamstring) - MNF
Head Coach Todd Bowles says DL Vita Vea (foot) is getting better and better and he'll get worked out on game day and hopefully will be able to play.
— Scott Smith (@ScottSBucs) November 25, 2022
