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Jaylen Warren
Facing depleted Bears D
Warren, who has no injury designation heading into Sunday's Week 12 matchup against the Bears after dealing with an ankle issue earlier in the week, will be facing a defense missing its three starting linebackers, Courtney Cronin of ESPN.com reports.
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Kenneth Gainwell
Could be Week 12 lead back
Gainwell could be Pittsburgh's top available running back in Week 12 against the Bears, as Teresa Varley of the Steelers' official site reports that Jaylen Warren did not participate in Wednesday's practice after sustaining an ankle injury in the Week 11 win over the Bengals.
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Bijan Robinson
Uptick in work likely Sunday
Robinson is projected to see additional touches in Sunday's Week 12 road matchup against the Saints because of the absence of Drake London due to a knee injury, Marc Raimondi of ESPN.com reports.
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Jaylen Warren
Likely to be available in Week 12
Head coach Mike Tomlin expressed optimism that Warren will be available for Sunday's matchup against the Bears, Brooke Pryor of ESPN reports.
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Emanuel Wilson
Could get start next Sunday
Wilson might be the starting running back for the Packers in Week 12 against the Vikings after Ian Rapoport of NFL Network reports that Josh Jacobs' knee injury could force him to miss time.
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Josh Jacobs
Status for Week 12 uncertain
Jacobs could miss a Week 12 clash with the Vikings due to a knee injury he sustained in Sunday's win over the Giants, Ian Rapoport of NFL Network reports.
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J.K. Dobbins
Likely done for year
Dobbins, who was placed on injured reserve Saturday due to a foot injury, will likely miss the remainder of the season unless the Broncos reach the Super Bowl, per Jeff Legwold of ESPN.com.
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Tahj Brooks
Slated for RB2 duties Week 11
Brooks should serve as the Bengals' No. 2 running back behind Chase Brown against the Steelers on Sunday due to Samaje Perine being ruled out with an ankle injury.
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TreVeyon Henderson
Another start on tap Thursday
Henderson will serve as the lead back in Thursday night's Week 11 matchup against the Jets due to Rhamondre Stevenson having been ruled out Wednesday because of his toe injury, Mike Reiss of ESPN.com reports.
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Rhamondre Stevenson
Third straight absence on tap
Stevenson will miss a third straight game Thursday night against the Jets due to his toe injury, Mike Reiss of ESPN.com reports.
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RJ Harvey
Likely headed for expanded role
Harvey would be in line for additional touches if J.K. Dobbins is sidelined by a foot injury, Parker Gabriel of the Denver Post reports.
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J.K. Dobbins
Could land on IR
Dobbins could be placed on injured reserve due to a foot injury, Chris Tomasson of The Denver Gazette reports.
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Devin Singletary
Unlikely to return to Giants
Singletary is a likely cap casualty for the Giants this offseason, Darryl Slater of NJ.com reports.
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Jonathan Taylor
Best rushing performance of 2025
Taylor became the fourth player in NFL history with multiple career games of 200-plus rushing yards and three-plus rushing touchdowns with his 244-yard, three-touchdown rushing performance in the Colts' Week 10 win over the Falcons in Berlin, per The Associated Press.
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D'Andre Swift
Facing competition for touches
Bears coach Ben Johnson suggested Friday that he'll employ a hot-hand approach to the backfield between Swift and Kyle Monangai in Week 10 against the Giants, per Courtney Cronin of ESPN.com.
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Kyle Monangai
Team will ride hot hand at RB
Bears coach Ben Johnson suggested Friday that he'll employ a hot-hand approach to the backfield between Monangai and D'Andre Swift in Week 10 against the Giants, per Courtney Cronin of ESPN.com.
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Rachaad White
Facing tough Pats defense
White will serve as the Buccaneers' starting running back for a fifth straight game after Bucky Irving was ruled out for Sunday's game against the Patriots, but the former will face a New England defense that has allowed a league-best 75.4 rushing yards per game this season, Jack Andrade of NFL.com reports.
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Rachaad White
May retain RB1 role after bye
White could continue his run atop Tampa Bay's running back depth chart in Week 10 against the Patriots, as Greg Auman of Fox Sports reports that Bucky Irving didn't practice Wednesday.
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TreVeyon Henderson
Set to maintain lead role Week 10
Henderson's likely to continue leading New England's backfield in Week 10 against the Buccaneers, as Evan Lazar of the Patriots' official site reports that Rhamondre Stevenson isn't participating in Thursday's practice due to a toe injury.
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Terrell Jennings
Could maintain elevated role
Jennings looks poised to maintain a significant role in Sunday's game against the Buccaneers, as Evan Lazar of the Patriots' official site reports that Rhamondre Stevenson isn't participating in Thursday's practice due to a toe injury.
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Breece Hall
Almost went to KC
Kansas City offered a fourth-round pick for Hall but the Jets opted not to trade him for that compensation at Tuesday's deadline, per Connor Hughes of Sportsnet New York.
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Ashton Jeanty
More pass-catching work coming?
Jeanty could be utilized more as a receiver out of the backfield over the second half of the season in the wake of the trade of Jakobi Meyers to the Jaguars on Tuesday, Ryan McFadden of ESPN.com reports.
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Breece Hall
Not dealt despite request
Hall was not moved at the deadline despite requesting a trade from the Jets, NFL reporter Jordan Schultz reports.
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Omarion Hampton
Not expected back until after bye
Hampton likely won't have his practice window opened until after the Chargers' Week 12 bye, Kris Rhim of ESPN.com reports.
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Jordan Mason
RB platoon-mate injured again
Mason could see an uptick in touches against the Ravens in Week 10, as Tom Pelissero of NFL Network reports that Aaron Jones suffered an AC joint sprain in his shoulder during Sunday's 27-24 win over the Lions.
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