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Jahmyr Gibbs
Extension candidate in offseason
Gibbs is expected to get a contract extension offer from the Lions once he's eligible this offseason, Ian Rapoport of NFL Network reports.
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Jordan Mason
Could be back in lead role Week 14
Mason could be in line to lead Minnesota's backfield in Week 14 against the Commanders, as Ben Goessling of The Minnesota Star Tribune reports that Aaron Jones injured his shoulder during Sunday's 26-0 loss to the Seahawks.
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Michael Carter
Could be Cardinals' RB1 for Week 13
Carter would be poised to lead the Cardinals' backfield against the Buccaneers on Sunday if Bam Knight is unable to play due to a knee injury.
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James Cook
Facing depleted Steelers front
Cook has played a big role in the Bills' league-best rushing attack this season, and he faces a Steelers defense Sunday that will be without rookie defensive lineman Derrick Harmon due to a knee injury, Brooke Pryor of ESPN reports.
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Ashton Jeanty
More carries under new OC?
Ryan McFadden of ESPN believes interim offensive coordinator Greg Olson will deploy more rushing plays for Jeanty for the rest of the regular season, starting with Sunday's AFC West tilt against the Chargers.
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Kimani Vidal
Retaining top role Sunday
Vidal is slated to serve as the Chargers' No. 1 running back in Sunday's game against the Raiders due to Omarion Hampton remaining on injured reserve, Kris Rhim of ESPN.com reports.
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Omarion Hampton
Remaining out in Week 13
Hampton, who's in the final stages of his recovery from an ankle fracture, has been ruled out for Sunday's Week 13 matchup against the Raiders, Kris Rhim of ESPN.com reports.
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Keaton Mitchell
Larger role expected Thursday
Mitchell's likely to see a bump in touches Thursday against the Bengals, as Justice Hill has been ruled out due to a neck injury.
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Kareem Hunt
Likely back to split with Pacheco
Hunt will likely return to a split backfield with Isiah Pacheco against the Cowboys on Thanksgiving Day, as head coach Andy Reid confirmed Tuesday that Pacheco will suit up Thursday, per Nate Taylor of ESPN.com.
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Emanuel Wilson
Set to retreat to backup role
Wilson is expected to be relegated to a backup role Thursday against the Lions, as Wes Hodkiewicz of the Packers' official site reports that Josh Jacobs does not carry an injury designation into the game.
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Josh Jacobs
Returning for Thanksgiving game
Jacobs does not carry an injury designation for Thursday's game against the Lions, per Wes Hodkiewicz of the Packers' official site, so the running back will return after missing one game due to a knee injury.
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Bucky Irving
Part-time role expected Sunday
Irving, who was listed as a full participant in Wednesday's walkthrough, will be slated for a part-time role if he's active for Sunday's Week 13 matchup against the Cardinals, Scott Smith of the team's official site reports.
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Trey Benson
Continues limited practices
Benson, who remains on injured reserve due to a knee injury, participated in limited fashion for the fourth consecutive practice Wednesday, Zach Gershman of the team's official site reports.
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Kimani Vidal
Uncertain role once Hampton returns
Vidal, who's been serving as the Chargers' No. 1 back for the majority of the time Omarion Hampton has been on injured reserve due to an ankle fracture, will still have a role to some degree once his teammate returns to action, Kris Rhim of ESPN.com reports.
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Omarion Hampton
Hoping for Week 13 return
Hampton, who returned to practice Tuesday after being designated to return from injured reserve, said he felt "amazing" being back on the field and was hoping the medical staff would clear him to play in Sunday's game against the Raiders, Kris Rhim of ESPN.com reports.
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Omarion Hampton
Likely to split reps upon return
Hampton isn't likely to be a workhorse back immediately upon his return from injured reserve, Kris Rhim of ESPN reports.
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Isiah Pacheco
Aiming for Thanksgiving return
Pacheco is hoping to return to the lineup in Week 13 against the Cowboys, Jeremy Fowler of ESPN.com reports.
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Dameon Pierce
Chooses KC among many suitors
Pierce is signing with Kansas City's practice squad, per Aaron Wilson of KPRC 2 Houston.
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Devin Neal
Could be starter with Kamara hurt
Neal could ascend to the top of the Saints' running back depth chart moving forward, as Alvin Kamara sustained a knee injury during Sunday's 24-10 loss to the Falcons.
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Cam Skattebo
Top 2025 rookie RB per MJD
Maurice Jones-Drew of NFL.com ranks Skattebo as the top running back in the 2025 rookie draft class in Thursday's hypothetical.
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Bucky Irving
Expected back in Week 13
Irving is expected to return in Week 13 against the Cardinals after having been sidelined since Week 4, Adam Schefter of ESPN reports.
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Jaylen Warren
Facing depleted Bears D
Warren, who has no injury designation heading into Sunday's Week 12 matchup against the Bears after dealing with an ankle issue earlier in the week, will be facing a defense missing its three starting linebackers, Courtney Cronin of ESPN.com reports.
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Kenneth Gainwell
Could be Week 12 lead back
Gainwell could be Pittsburgh's top available running back in Week 12 against the Bears, as Teresa Varley of the Steelers' official site reports that Jaylen Warren did not participate in Wednesday's practice after sustaining an ankle injury in the Week 11 win over the Bengals.
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Bijan Robinson
Uptick in work likely Sunday
Robinson is projected to see additional touches in Sunday's Week 12 road matchup against the Saints because of the absence of Drake London due to a knee injury, Marc Raimondi of ESPN.com reports.
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Jaylen Warren
Likely to be available in Week 12
Head coach Mike Tomlin expressed optimism that Warren will be available for Sunday's matchup against the Bears, Brooke Pryor of ESPN reports.
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