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Brandon Aiyuk
Won't return in 2025
Aiyuk was placed on the reserve/left squad list Saturday, per Matt Barrows of The Athletic, which rules the wide receiver out from returning during the 2025 season.
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Jacory Croskey-Merritt
Could have expanded Week 15 role
Croskey-Merritt could see more opportunities in Week 15 against the Giants, as Adam Schefter of ESPN reports that Chris Rodriguez will be a game-time decision due to a groin injury.
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Josh Jacobs
Expected to play in Week 15
Jacobs is expected to play through his knee injury in Week 15 against the Broncos, per Adam Schefter of ESPN.
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Alec Pierce
Facing likely QB downgrade
Pierce will have Philip Rivers as his quarterback against the Seahawks in Week 15, Ian Rapoport of NFL Network reports.
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Michael Pittman
Catching passes from Rivers
Pittman will have Philip Rivers as his quarterback against the Seahawks in Week 15, Ian Rapoport of NFL Network reports.
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Philip Rivers
Set for first start in five years
Rivers will start for the Colts against the Seahawks in Week 15, Ian Rapoport of NFL Network reports.
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Lil'Jordan Humphrey
Slated for more snaps sans Bryant
Humphrey is set to take on an expanded role on offense against the Packers on Sunday due to the absence of Pat Bryant, Chris Tomasson of The Denver Gazette reports.
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Christian McCaffrey
Close to yardage milestone
McCaffrey needs just 145 more yards from scrimmage to reach the 1,800-yard mark for the fifth time in his NFL career, per NFL.com.
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Jahmyr Gibbs
Close to surpassing TD record
Gibbs has 47 receiving or rushing touchdowns since entering the league in 2023, and with one more score, he would surpass Hall of Fame running back Barry Sanders for the most touchdowns by a player both in their first three career seasons and before their 24th birthday, per NFL.com.
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Trey McBride
Closing in on history
McBride is just seven catches away from becoming the first tight end in NFL history to record at least 100 receptions in consecutive seasons, per NFL.com.
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Philip Rivers
Hall of Fame clock resetting
Rivers' eligibility for the Hall of Fame has been pushed back to 2031 after he was signed from the practice squad to the Colts' active roster Saturday, Mike Chappell of Fox 59 News Indianapolis reports.
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Ladd McConkey
Tough matchup vs. Kansas City
McConkey has mostly operated out of the slot in 2025, and he could struggle Sunday against a Chiefs defense that has limited targets to players lined up in the slot position this season, Seth Walder of ESPN.com relays.
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Andrei Iosivas
Expanded role on tap
Iosivas will operate as the Bengals' WR2 against the Ravens on Sunday after Tee Higgins was ruled out due to a concussion, Ben Baby of ESPN.com reports.
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Dak Prescott
Resistant to Vikings blitz?
Prescott has done well against the blitz this season, and that could translate well Sunday against a Vikings defense that blitzes more than any other team in the NFL, Calvin Watkins of The Dallas Morning News reports.
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DJ Moore
Trade candidate in 2026?
Moore is in the midst of his least productive season since his rookie campaign in 2018, and his base salary owed through 2029 makes him a trade candidate in the offseason, Kevin Fishbain of The Athletic notes.
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Shedeur Sanders
Could be down two pass catchers
Sanders may face the Bears in Sunday's interconference matchup without two starting pass catchers, Daniel Oyefusi of ESPN.com reports.
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Harold Fannin
Set for enhanced role Sunday
Fannin will be set for even more targets during Sunday's Week 15 matchup against the Bears due to David Njoku having been ruled out with a knee injury, Daniel Oyefusi of ESPN.com reports.
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David Njoku
Ruled out vs. Bears
Njoku has been ruled out for Sunday's Week 15 matchup against the Bears due to a knee injury, Daniel Oyefusi of ESPN.com reports.
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Stefon Diggs
High praise for Maye
Diggs said this week that Drake Maye's maturation process during his second season has been "second to none," Conor Ryan of Boston.com reports.
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Joe Burrow
Working short-handed again Sunday
Burrow will work without No. 2 receiver Tee Higgins for the second time in the last three games Sunday against the Ravens due to the latter having been ruled out because of a concussion, Ben Baby of ESPN.com reports.
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Ja'Marr Chase
Set for target bump in Week 15
Chase is due for even more targets than usual in Sunday's Week 15 matchup against the Ravens as a result of Tee Higgins being sidelined due to a concussion, Ben Baby of ESPN.com reports.
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Mitchell Tinsley
Added opportunity on tap Sunday
Tinsley is projected for additional opportunities in Sunday's Week 15 matchup against the Ravens since Tee Higgins has been ruled out for the contest due to a concussion, Ben Baby of ESPN.com reports.
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Tee Higgins
Ruled out for Week 15
Higgins has been ruled out for Sunday's game against the Ravens due to a concussion, Ben Baby of ESPN.com reports.
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Brady Cook
Chances of Week 15 start rising
Cook's chances of making his first NFL start Sunday against the Jaguars seem to be increasing, as Rich Cimini of ESPN.com reports that Tyrod Taylor and Justin Fields were both sidelined for a second consecutive practice Thursday due to their respective groin and knee injuries.
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Emanuel Wilson
Could get more Week 15 carries
Wilson could see an expanded workload Sunday against the Broncos, as Matt Schneidman of The Athletic reports that Josh Jacobs didn't practice Thursday and is day-to-day due to a knee injury.
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