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Texans vs Bills Odds, Lines, Spreads & Totals 2025

Bills
Texans
Thursday November 20, 2025 at 8:15 PM ET
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BUF
Bills Injury Report
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HOU
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BUF
Bills Lineup
Inactives
HOU
Texans Lineup
Inactives
BUF
Bills News
#2 RB
Ty Johnson: Solid as receiver in loss
Nov 20th
Johnson rushed twice for seven yards and brought in all three targets for 45 yards in the Bills' 23-19 loss to the Texans on Thursday night. He also returned one kickoff for 22 yards.
#1 WR
Khalil Shakir: Eclipses century mark in loss
Nov 20th
Shakir secured eight of 10 targets for 110 yards in the Bills' 23-19 loss to the Texans on Thursday night. He also lost a fumble and returned four punts for 15 yards.
#1 K
Matt Prater: Makes both FGAs in loss
Nov 20th
Prater went 2-for-2 on field-goal tries and made one of two PATs in Thursday night's 23-19 loss to the Texans.
#1 RB
James Cook: Nets 129 total yards, TD in loss
Nov 20th
Cook rushed 17 times for 116 yards and a touchdown while bringing in all three targets for 13 yards in the Bills' 23-19 loss to the Texans on Thursday night.
#1 QB
Josh Allen: Struggles against Texans in loss
Nov 20th
Allen completed 25 of 35 passes for 262 yards with no touchdowns and two interceptions in the Bills' 23-19 loss to the Texans on Thursday night. He also rushed five times for 20 yards.
#1 MLB
Terrel Bernard: Ruled out Thursday
Nov 20th
Bernard (elbow) has been ruled out for the rest of Thursday night's matchup with the Texans.
#4 TE
Keleki Latu: Elevated for TNF
Nov 20th
Buffalo elevated Latu from the practice squad ahead of Thursday night's game against the Texans.
#3 LDT
Phidarian Mathis: Not yet ready to return
Nov 20th
Mathis (shoulder) is inactive for Thursday's Week 12 matchup against Houston.
#5 WR
Keon Coleman: Inactive versus Houston
Nov 20th
Coleman is inactive for Thursday night's game against the Texans.
#4 WR
Gabe Davis: Elevated for second straight week
Nov 20th
The Bills elevated Davis from the practice squad ahead of Thursday's game against the Texans.
#8 WR
Mecole Hardman: Lands on IR
Nov 20th
Hardman (calf) was placed on IR by the Bills on Thursday.
#1 RCB
Christian Benford: Ready for Thursday
Nov 19th
Benford (groin) has no injury designation ahead of Thursday night's matchup against the Texans.
#6 WR
Curtis Samuel: Won't play Thursday
Nov 19th
Samuel (elbow/neck) has been ruled out ahead of Thursday's matchup against the Texans.
#2 WR
Joshua Palmer: Ready to face Texans
Nov 19th
Palmer (knee/ankle) was a full participant in Wednesday's practice and does not carry an injury designation for Thursday's game against the Texans.
#1 TE
Dalton Kincaid: Ruled out for TNF
Nov 19th
Bills coach Sean McDermott said Wednesday that Kincaid (hamstring) is ruled out for Thursday's road contest against the Texans, Alaina Getzenberg of ESPN.com reports.
#2 WLB
Shaq Thompson: Full practice at walkthrough
Nov 17th
Thompson (hamstring) was listed as a full participant on Monday's estimated practice report.
#3 TE
Jackson Hawes: Fails to catch pass in Week 11 win
Nov 17th
Hawes wasn't targeted in the Bills' 44-32 win over the Buccaneers on Sunday.
#3 RB
Ray Davis: Impact limited to return game again
Nov 17th
Davis played one of 56 offensive snaps during Buffalo's 44-32 win over the Buccaneers in Week 11. He also returned four kickoffs for 158 yards.
#1 FS
Cole Bishop: Nabs another pick in win
Nov 17th
Bishop recorded six total tackles (three solo) and one interception in Sunday's 44-32 win over the Buccaneers.
#1 SS
Jordan Poyer: Notches 15 stops vs. Tampa Bay
Nov 17th
Poyer recorded 15 total tackles (seven solo) and one pass defensed in Sunday's 44-32 win over the Buccaneers.
#2 TE
Dawson Knox: Catches one pass in Week 11 win
Nov 17th
Knox caught one of three targets for 23 yards in Sunday's 44-32 win over Tampa Bay.
#3 WR
Tyrell Shavers: Makes most of added opportunities
Nov 16th
Shavers caught four of five targets for 90 yards and a touchdown in Sunday's 44-32 win over the Buccaneers.
#2 SCB
Cam Lewis: Active Sunday, as is Taron Johnson
Nov 16th
Lewis (calf) is active for Sunday's Week 11 battle against the Buccaneers.
#7 WR
Elijah Moore: Inactive Sunday
Nov 16th
Moore is inactive for Sunday's game against the Buccaneers.
#1 SCB
Taron Johnson: Cleared for Week 11
Nov 16th
Johnson (groin) is active for Sunday's tilt against Tampa Bay.
#3 DT2
T.J. Sanders: Activated from IR
Nov 15th
The Bills activated Sanders (knee) from injured reserve Saturday, though he is still listed as questionable for Sunday's game against Tampa Bay.
#2 LDE
A.J. Epenesa: Good to go
Nov 14th
Epenesa (concussion) has no injury designation ahead of Sunday's matchup against the Buccaneers.
#1 RDE
Joey Bosa: Logs four stops Sunday
Nov 11th
Bosa logged four solo tackles during Buffalo's loss to Miami on Sunday.
#3 LDE
Landon Jackson: Placed on IR
Nov 11th
The Bills placed Jackson (knee) on injured reserve Tuesday.
#1 DT2
DaQuan Jones: Cleared to play Miami
Nov 9th
Jones (calf) is active for Sunday's game against the Dolphins.
HOU
Texans News
#2 RB
Nick Chubb: Minor impact in Week 12 win
Nov 20th
Chubb rushed six times for 16 yards and brought in his only target for minus-5 yards in the Texans' 23-19 win over the Bills on Thursday night.
#2 WR
Jayden Higgins: Records fourth TD in win
Nov 20th
Higgins brought in four of nine targets for 38 yards and a touchdown in the Texans' 23-19 win over the Bills on Thursday night.
#3 WR
Christian Kirk: Records TD in Week 12 win
Nov 20th
Kirk brought in five of six targets for 54 yards and a touchdown in the Texans' 23-19 win over the Bills on Thursday night.
#1 RB
Woody Marks: Solid as lead back in win
Nov 20th
Marks rushed 16 times for 74 yards and brought in his only target for minus-5 yards in the Texans' 23-19 win over the Bills on Thursday night.
#2 QB
Davis Mills: Two TD tosses in win
Nov 20th
Mills completed 16 of 30 passes for 153 yards with two touchdowns and no interceptions while adding two carries for four yards in the Texans' 23-19 win over the Bills on Thursday night.
#1 WR
Nico Collins: Held in check after halftime
Nov 20th
Collins brought in all three targets for 55 yards in the Texans' 23-19 win over the Bills on Thursday night.
#1 K
Ka'imi Fairbairn: Makes three FGAs in return
Nov 20th
Fairbairn went 3-for-3 on field-goal attempts and made both of his PATs in Thursday night's 23-19 win over the Bills.
#2 RCB
Ajani Carter: Hurts hamstring Week 12
Nov 20th
Carter has been ruled out for the remainder of Thursday's game against Buffalo due to a hamstring injury.
#6 WR
Braxton Berrios: Healthy scratch again Week 12
Nov 20th
Berrios (coach's decision) is inactive for Thursday's matchup against Buffalo.
#5 RB
Joe Mixon: Not expected to return this season
Nov 20th
Mixon (foot/ankle) is not expected to suit up during the 2025 campaign, Ian Rapoport of NFL Network reports.
#3 ROLB
Damone Clark: Claimed by Texans
Nov 19th
The Texans claimed Clark off waivers Wednesday.
#1 RT
Tytus Howard: Good to go vs. Bills
Nov 19th
Howard (knee/ankle) doesn't have an injury designation for Houston's matchup versus the Bills on Thursday.
#2 ROLB
Jamal Hill: Won't play vs. Bills
Nov 19th
Hill (hamstring) has been ruled out for Houston's matchup versus Buffalo on Thursday.
#1 MLB
Azeez Al-Shaair: Cleared to play TNF
Nov 19th
Al-Shaair (knee/illness) does not have an injury designation ahead of Thursday's game against Buffalo.
#1 LDE
Will Anderson: Good to go against Buffalo
Nov 19th
Anderson (ankle) does not carry an injury designation into Thursday's game against the Bills.
#1 TE
Dalton Schultz: Turns in full practice
Nov 18th
Schultz (shoulder) was a full participant in Tuesday's practice.
#1 SCB
Jalen Pitre: Ruled out for TNF
Nov 18th
Coach DeMeco Ryans said Pitre (concussion) will not play in Thursday night's game against the Bills, DJ Bien-Aime of ESPN.com reports.
#1 QB
C.J. Stroud: Ruled out for Thursday night
Nov 18th
Texans head coach DeMeco Ryans ruled Stroud (concussion) out for Thursday's game against the Bills, DJ Bien-Aime of ESPN.com reports.
#1 SS
Calen Bullock: Makes six stops again Sunday
Nov 17th
Bullock finished Sunday's 16-13 win over Tennessee with six tackles (three solo).
#1 RCB
Kamari Lassiter: Posts two stops in Week 11 win
Nov 17th
Lassiter recorded two tackles (one solo) and a defensed pass Sunday in a 16-13 victory versus Tennessee.
#2 SCB
Myles Bryant: Paces Texans in tackles Sunday
Nov 17th
Bryant logged eight tackles (four solo) in Sunday's 16-13 win against Tennessee.
#1 RG
Ed Ingram: Returns to full practice
Nov 17th
Ingram (knee) was estimated to be a full practice participant Monday.
#1 RDE
Danielle Hunter: Another dominant performance Sunday
Nov 17th
Hunter recorded four total tackles (one solo), including 1.5 sacks, in Sunday's 16-13 win over the Titans.
#4 WR
Jaylin Noel: Up-and-down season continues
Nov 17th
Noel hauled in his lone target for 12 yards while adding 89 total return yards on five punts and two kickoffs in Sunday's 16-13 win over the Titans in Week 11.
#2 TE
Cade Stover: Untargeted in win
Nov 17th
Stover played 14 snaps and was not targeted in Sunday's 16-13 win over the Titans in Week 11.
#5 WR
Xavier Hutchinson: Posts 42 yards in Week 11 win
Nov 16th
Hutchinson caught three of five targets for 42 yards in the Texans' 16-13 win over the Titans on Sunday.
#1 FB
Jakob Johnson: Ready for Week 11
Nov 16th
Johnson (hamstring) is active for Sunday's game against the Titans.
#3 TE
Harrison Bryant: Placed on injured reserve
Nov 15th
The Texans placed Bryant (neck/shoulder) on injured reserve Saturday.
#2 MLB
Christian Harris: Returns to full practice
Nov 13th
Harris (shin) practiced in full Thursday.
#2 SS
M.J. Stewart: Officially lands on IR
Nov 12th
Stewart (quadriceps) was placed on injured reserve Wednesday.
#1 LCB
Derek Stingley: Records third pickoff
Nov 11th
Stingley registered two assisted tackles and two defensed passes, including an interception, in a 36-29 win against the Jaguars on Sunday.